General Information |
|
Product |
Ephrin Receptor A7 Antibody BIOTIN |
Description |
BIOTIN-Conjugated Ephrin type-A receptor 7 isoform 1 precursor Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding taken within amino acid region 500-550 on human Ephrin type-A receptor 7 protein. |
Accession # |
NCBI: NP_004431 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55-0.75 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation | 1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. |
Molecular Function |
Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Cell membrane, Single-pass type 1 membrane protein |
Expression |
Widely Expressed |
Structure |
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK1 |
Alternative Nomenclature |
Cek 11 antibody Developmental kinase 1 antibody EBK antibody EHK3 antibody EK11 antibody Embryonic brain kinase antibody Eph homology kinase 3 antibody Eph receptor A7 antibody EPH-like kinase 11 antibody EphA7 antibody Ephrin type-A receptor 7 antibody hEK11 antibody MDK 1 antibody Receptor protein tyrosine kinase HEK 11 antibody Tyrosine protein kinase receptor EHK 3 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-EPHAR7 | |||
|
EPHAR7-701AP | |||
|
EPHAR7-FITC | |||
|
PC-EPHAR7 | |||
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