General Information |
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Product |
Eprhin Receptor B4 Positive Control |
Description |
Western Blot Positive Control Ephrin type-B receptor 4 Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
NCBI: NP_004435 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis. |
Molecular Function |
ATP-binding, Nucleotide-binding |
Subcellular Location |
Cell Membrane |
Expression |
Abundantly expressed in placenta but also detected in kidney, liver, lung, pancreas, skeletal muscle and heart. Expressed in primitive and myeloid, but not lymphoid, hematopoietic cells. Also observed in cell lines derived from liver, breast, colon, lung, melanocyte and cervix. |
Structure |
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. |
Alternative Nomenclature |
Ephb4 antibody Ephrin type-B receptor 4 antibody Hepatoma Transmembrane Kinase antibody HTK antibody MYK 1 antibody MYK1 antibody TYRO 11 antibody Tyrosine-protein kinase receptor HTK antibody Tyrosine-protein kinase TYRO11 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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EPHBR4-401AP | |||
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EPHBR4-FITC | |||
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P-EPHBR4 | |||
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EPHBR4-BIOTIN | |||
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