General Information
|
|
Product
|
IL18RAP Antibody BIOTIN
|
Description
|
BIOTIN-Conjugated Interleukin-18 receptor accessory protein Antibody
|
Verified Applications
|
ELISA, IP, WB
|
Host
|
Rabbit
|
Species Cross Reactivity
|
Human, Rat
Predicted: Mouse
|
Immunogen
|
Synthetic peptide taken within amino acid region 500-550 on human Interleukin-18 receptor accessory protein.
|
Physical Properties
|
|
Quantity
|
100 µg
|
Volume
|
200 µl
|
Concentration
|
0.5 µg/µl in antibody stabilization buffer
|
Immunoglobulin
|
IgG
|
Form
|
BIOTIN-Conjugated
|
Purification Method
|
Immobilized antigen affinity chromatography
|
Clonality
|
Polyclonal
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
ELISA
|
1:10,000
|
Immunoprecipitation
|
1:150
|
Western Blot
|
1:500
|
Protein
|
Uniprot #
|
O95256
|
Overview
|
Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation.
|
Molecular Function
|
Receptor activity
|
Subcellular Location
|
Membrane, Single-pass type I membrane protein
|
Expression
|
Strongly expressed in peripheral blood leukocytes, spleen, lung, and, to a lesser extent, in colon, but not in any other tissue tested. Strongly expressed in T-cells polarized with IL-12. Specifically coexpressed with IL18R1 in Th1 cells.
|
Structure
|
Belongs to the interleukin-1 receptor family.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 TIR domain.
|
Alternative Nomenclature
|
IL18RAP antibody
Accessory protein like antibody
AcPL antibody
CD218 antigen-like family member B antibody
CDw218b antibody
IL-18R-beta antibody
IL-18RAcP antibody
IL-18Rbeta antibody
IL-1R accessory protein-like antibody
IL-1R7 antibody
IL-1RAcPL antibody
IL18RAP antibody
IL18Rbeta antibody
Interleukin 18 receptor accessory protein antibody
Interleukin-1 receptor 7 antibody
Interleukin-18 receptor beta antibody
|
|
|