General Information
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Product
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p63 Peptide
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Description
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Antigenic Blocking Peptide Tumor protein 63 isoform 6 Antibody
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Verified Applications
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Immunocompeition, Immunodepletion
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Peptide Description
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Synthetic peptide taken within amino acid region 1-100 on human p63 protein.
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Accession #
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NCBI: NP_001108454
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9H3D4
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Overview
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Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
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Molecular Function
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Activator, Developmental protein, chromatin binding
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Subcellular Location
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Nucleus
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Expression
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Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.
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Structure
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Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L.
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Alternative Nomenclature
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AIS antibody
Amplified in squamous cell carcinoma antibody
B(p51A) antibody
B(p51B) antibody
Chronic ulcerative stomatitis protein antibody
CUSP antibody
DN p63 alpha 1 antibody
EEC3 antibody
Keratinocyte transcription factor antibody
KET antibody
LMS antibody
MGC115972 antibody
MGC192897 antibody
NBP antibody
OFC8 antibody
p40 antibody
p51 antibody
P51/P63 antibody
p53CP antibody
p63 antibody
P73 antibody
p73H antibody
p73L antibody
RHS antibody
SHFM4 antibody
TAp63alpha antibody
TP53CP antibody
TP53L antibody
TP63 antibody
TP73 antibody
Transformation related protein 63 antibody
Trp53rp1 antibody
Trp63 antibody
Tumor protein 63 antibody
Tumor protein p53-competing protein antibody
Tumor protein p63 deltaN isoform delta antibody
Tumor protein p73 antibody
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