General Information
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Product
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CCR4 Antibody FITC-Conjugated
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Description
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FITC-Conjugated C-C chemokine receptor type 4 Antibody
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Verified Applications
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CF, DB, ELISA, IF, IHC, IMM, WB
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Host
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Rabbit
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Species Cross Reactivity
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Cat, Human, Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.
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Accession #
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NCBI: NP_005499
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.68 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:250
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Immunocytochemistry
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1:250
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Immunofluorescence
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1:250
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Immunohistochemistry
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1:250
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Immunoprecipitation
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1:250
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Western Blot
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1:500
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Protein
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Uniprot #
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P51679
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Overview
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Receptor for C-C type chemokines CCL17/TARC and CCL22/MDC. Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates. Can also mediate hippocampal-neuron survival.
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Molecular Function
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GPCR, Receptor, Transducer.
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Subcellular Location
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Cell membrane; Multi-pass membrane protein
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Expression
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Thymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets. Expressed less in spleen and in monocytes. Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen. Expressed in brain and microvascular and coronary artery endothelial cells.
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Structure
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Belongs to G-protein coupled receptor 1 family. Interacts with CREB3.
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Alternative Nomenclature
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CD194 antibody
ChemR13 antibody
CKR4 antibody
CMKBR 4 antibody
HGCN 14099 antibody
K5 5 antibody
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