General Information |
|
Product |
Pan PDE3B Antibody FITC |
Description |
FITC-Conjugated cGMP-inhibited 3',5'-cyclic phosphodiesterase B Antibody |
Verified Applications |
CM, ELISA, ICC, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Chicken, Human, Monkey, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1060-1110 on human PDE3B protein. |
Specificity | This antibody does not cross react with PDE4A variants nor with any other PDE famly members. This antibody will recognize PDE3B variants. |
Accession # |
GenBank: BAA09306 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.70 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:250 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:250 |
Immunofluorescence |
1:250 |
Immunohistochemistry |
1:250 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Regulates cAMP binding of RAPGEF3. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Membrane; Multipass membrane protein |
Expression |
Abundant in adipose tissues. |
Structure |
Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6 (By similarity). |
Alternative Nomenclature |
5''-cyclic phosphodiesterase B antibody adipocyte cAMP phosphodiesterase cGMP inhibited antibody AI847709 antibody cAMP Phosphodiesterase, adipocyte, cGMP-inhibited antibody CGIP1 antibody CGIPDE B antibody cGMP inhibited 3 5 cyclic phosphodiesterase B antibody CGMP inhibited cAMP phophodiesterase antibody cGMP-inhibited 3'' antibody Cyclic GMP-inhibited phosphodiesterase B antibody Cyclic nucleotide phosphodiesterase antibody HcGIP1 antibody Phosphodiesterase 3B cGMP inhibited antibody |
Protein information supplied by UniProt
Fabgennix PDE3B Antibody has been used in 3 Publications |
|
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602
|
Immunohistochemistry, Human |
Dov, Avital, et al. "Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose." Endocrinology 149.2 (2008): 741-748. PMID17991719
|
Western Blot; Rat |
Netherton, Stuart J., and Donald H. Maurice. "Vascular endothelial cell cyclic nucleotide phosphodiesterases and regulated cell migRation: implications in angiogenesis." Molecular pharmacology 67.1 (2005): 263-272. PMID15475573
|
Western Blot; Bovine, Human |
Publishing research using PD3B-101AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PD3B-101AP | |||
|
P-PD3B.101 | |||
|
PD3B.101-BIOTIN | |||
|
PC-PD3B | |||
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