General Information |
|
Product |
Phospho-ErbB 2 Antibody BIOTIN |
Description |
BIOTIN-Conjugated Receptor tyrosine-protein kinase erB-2 (HER2) Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat Predicted: Human |
Immunogen |
Phoshporylated synthetic peptide taken within amino acid region 1100-1150 on human HER-2 protein |
Accession # |
GenBank: AAA75493.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). |
Molecular Function |
Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Subcellular Location |
Isoform 1: Cell membrane; Single-pass type I membrane protein, Cytoplasm>perinuclear region, Nucleus. Isoform 2: Cytoplasm, Nucleus. Isoform 3: Cytoplasm, Nucleus. |
Expression |
Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. |
Structure |
Homodimer. Heterodimer with EGFR, ERBB3 and ERBB4. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with PRKCABP and PLXNB1. Interacts (when phosphorylated on Tyr-1248) with MEMO1. Interacts with MUC1; the interaction is enhanced by heregulin (HRG). |
Alternative Nomenclature |
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog antibody c erb B2/neu protein antibody CD340 antibody CerbB2 antibody Erb B2 antibody Erythroblastosis Virus antibody HER 2/neu antibody Herstatin antibody Metastatic lymph node gene 19 protein antibody MLN19 antibody NEU antibody Neuro Glioblastoma Derived Oncogene Homolog antibody NGL antibody p185 ErbB2 antibody Receptor Protein Tyrosine Kinase ErbB2 Precursor antibody TKR1 antibody Tyrosine kinase-type cell surface receptor HER2 antibody v erb b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) antibody verbb2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PHER2 | |||
|
PHER-240AP | |||
|
PHER2-FITC | |||
|
PC-PHER2 | |||
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