General Information
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Product
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PREX1 Antibody BIOTIN-Conjugated
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Description
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BIOTIN-Conjugated Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified.
Sequence:
QEEDQADSAFPLLSLGPRLSLC
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.6 µg/µl in antibody stabilization buffer
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Form
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BIOTIN-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:20,000-1:50,000
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ELISA
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1:20,000-1:50,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot
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1:500-1:750
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Protein
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Uniprot #
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Q8TCU6
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Overview
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Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
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Molecular Function
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enzyme binding, Rho GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, phospholipid binding
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Subcellular Location
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Cytoplasm, cell membrane
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Expression
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Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
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Alternative Nomenclature
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4 antibody
5)-dependent Rac exchanger 1 antibody
P REX1 antibody
PtdIns(3,4,5) dependent Rac exchanger 1 antibody
SET domain containing 6 antibody
Setd6 antibody
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