General Information
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Product
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Pan PDE2A Antibody FITC-Conjugated
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Description
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FITC-Conjugated Phosphodiesterase 2A, cGMP-stimulated Antibody C-epitope
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Verified Applications
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CM, ELISA, FRET, ICC/IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to unique C-terminal amino acid sequence on PDE2A gene.
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Specificity |
This antibody will label PDE2A1, PDE2A2, PDE2A3 and PDE2A4 variants. |
Accession #
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GenBank: EAW74861.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.7 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Determinant
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C-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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Confocal Microscopy
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1:250-1:1,000
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DB
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1:10,000
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ELISA
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1:10,000
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Immunocytochemistry
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1:250-1:1,000
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Immunofluorescence
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1:150-1:1,000
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Immunohistochemistry
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1:250-1:1,000
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Immunoprecipitation
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1:200
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Western Blot
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1:250-1:1,000
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Protein
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Uniprot #
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UPI000003B340
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Overview
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Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
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Molecular Function
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Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis
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Subcellular Location
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Multi-pass membrane protein
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Expression
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bundant in adipose tissues.
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Structure
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Interacts with PIK3CG. Interacts with RAPGEF3 and PIK3R6.
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Alternative Nomenclature
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5''-cyclic phosphodiesterase antibody
cGMP dependent 3'5' cyclic phosphodiesterase antibody
cGMP stimulated phosphodiesterase 1 antibody
cGMP stimulated phosphodiesterase 4 antibody
cGMP-dependent 3'' antibody
CGS PDE antibody
Cyclic GMP stimulated phosphodiesterase antibody
PDE 2A antibody
PDE 2A1 antibody
PDE 2A4 antibody
PDE2A antibody
Phosphodiesterase 2A cGMP stimulated antibody
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