General Information
|
|
Product
|
DDIT3 Peptide
|
Description
|
Antigenic Blocking Peptide DNA damage-inducible transcript 3 protein Antibody
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide taken within amino acid region 60-160 on human GADD153 protein.
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
P35638
|
Overview
|
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes.
|
Molecular Function
|
Activator, Repressor, DNA binding
|
Subcellular Location
|
Cytoplasm, Nucleus
|
Structure
|
Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC1, HDAC5 and HDAC6. Interacts with TRIB3 which blocks its association with EP300/P300. Interacts with FOXO3, CEBPB and ATF4.
|
Alternative Nomenclature
|
C/EBP homologous protein antibody
C/EBP zeta antibody
CCAAT/enhancer binding protein homologous protein antibody
CEBPZ antibody
CHOP 10 antibody
DDIT3 antibody
DNA Damage Inducible Transcript 3 antibody
GADD153 antibody
Growth Arrest and DNA Damage Inducible Protein 153 antibody
MGC4154 antibody
|
|
|