General Information

Product

NAPSIN A Antibody

Description

Affinity Purified Napsin A aspartic peptidase Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human Napsin A protein.

Accession #

GenBank: EAW71848.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85-1.25 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O96009

Overview

May be involved in processing of pneumocyte surfactant precursors

Molecular Function

aspartic-type endopeptidase activity; peptidase activity

Subcellular Location

alveolar lamellar body; extracellular space; extracellular vesicular exosome; lysosome

Expression

Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.

Structure

Belongs to the peptidase A1 family.

Alternative Nomenclature

ASP 4 antibody Aspartyl protease 4 antibody
KAP antibody
Kdap antibody
Kidney derived aspartic protease like protein antibody
NAP1 antibody
NAPA antibody
NAPSA antibody

Napsin 1 antibody
napsin A aspartic peptidase antibody Pronapsin A antibody
SNAPA antibody
TA01/TA02 antibody

General Information

Product

NAPSIN A Antibody

Description

Affinity Purified Napsin A aspartic peptidase Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-300 on human Napsin A protein.

Accession #

GenBank: EAW71848.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85-1.25 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O96009

Overview

May be involved in processing of pneumocyte surfactant precursors

Molecular Function

aspartic-type endopeptidase activity; peptidase activity

Subcellular Location

alveolar lamellar body; extracellular space; extracellular vesicular exosome; lysosome

Expression

Expressed predominantly in adult lung (type II pneumocytes) and kidney and in fetal lung. Low levels in adult spleen and very low levels in peripheral blood leukocytes.

Structure

Belongs to the peptidase A1 family.

Alternative Nomenclature

ASP 4 antibody Aspartyl protease 4 antibody
KAP antibody
Kdap antibody
Kidney derived aspartic protease like protein antibody
NAP1 antibody
NAPA antibody
NAPSA antibody

Napsin 1 antibody
napsin A aspartic peptidase antibody Pronapsin A antibody
SNAPA antibody
TA01/TA02 antibody

General Information

Product

ZMPSTE24 Antibody

Description

Affinity Purified CAAX prenyl protease 1 homolog Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse

Immunogen

Synthetic peptide taken within amino acid region 450-480 on mouse ZMPSTE24 protein.

Accession #

NCBI:  NP_766288

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q80W54

Overview

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.

Molecular Function

Metal ion binding

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein; Nucleus inner membrane; Multi-pass membrane protein

Alternative Nomenclature

CAAX prenyl protease 1 homolog antibody

FACE-1 antibody

Farnesylated proteins-converting enzyme 1 antibody

Prenyl protein specific endoprotease 1 antibody

STE24 antibody

Zinc metalloproteinase Ste24 homolog antibody

zmpste24 antibody

General Information

Product

ZMPSTE24 Antibody Affinity Purified

Description

Affinity Purified CAAX prenyl protease 1 homolog Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Rat, Mouse

Immunogen

Synthetic peptide taken within amino acid region 450-480 on mouse ZMPSTE24 protein.

Accession #

NCBI:  NP_766288

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q80W54

Overview

Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C.

Molecular Function

Metal ion binding

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein; Nucleus inner membrane; Multi-pass membrane protein

Alternative Nomenclature

CAAX prenyl protease 1 homolog antibody

FACE-1 antibody

Farnesylated proteins-converting enzyme 1 antibody

Prenyl protein specific endoprotease 1 antibody

STE24 antibody

Zinc metalloproteinase Ste24 homolog antibody

zmpste24 antibody

General Information

Product

PCSK9 Antibody

Description

Affinity Purified Proprotein convertase subtilisin/kexin type 9 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 30-60 on the NARC1 protein.

Accession #

NCBI:  NP_705793.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.85-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q80W65

Overview

Crucial player in the regulation of plasma cholesterol homeostasis

Molecular Function

Hydrolase, Protease, Serine protease

Subcellular Location

Cytoplasm, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Secreted

Expression

Hepatocytes, kidney mesenchymal cells, intestinal ileum, colon epithelia and embryonic brain telencephalon neurons.

Structure

Monomer. Can self-associate to form dimers and higher multimers,Belongs to the peptidase S8 family

Alternative Nomenclature

Convertase subtilisin/kexin type 9 preproprotein antibody

FH3 antibody

HCHOLA3 antibody

LDLCQ1 antibody

NARC 1 antibody

PC 9 antibody

PCSK9 antibody

PSEC0052 antibody

General Information

Product

Presenilin 2 Antibody Affinity Purified

Description

Affinity Purified Presenilin-2 isoform 1 Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein.

Accession #

NCBI:  NP_036618

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

1.00-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P49810

Overview

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.

Molecular Function

Hydrolase, Protease, aspartic-type endopeptidase activity

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein

Expression

Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.

Structure

Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a

Alternative Nomenclature

AD 3LP antibody

AD 4 antibody

AD 5 antibody

Alzheimer disease 4 antibody

CMD1V antibody

E5 1 antibody

Presenilin 2 (Alzheimer disease 4) antibody

PS2 antibody

PSEN 2 antibody

STM2 antibody

General Information

Product

Aph 1b Antibody

Description

Affinity Purified Presenelin-stabiliziation factor-like Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

C. elegans, Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 235-257 of Human Presenilin stabilizing protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8WW43

Overview

Subunit of gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and beta-amyloid precursor protein.

Molecular Function

Notch signaling pathway

Subcellular Location

Membrane; Multi-pass protein

Expression

Weakly expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, thymus, colon, skeletal muscle, heart, and brain.

Structure

Component of gamma-secretase complex.  Interacts with PSEN1 and PSEN2.

Alternative Nomenclature

Anterior pharynx defective 1B like antibody

Gamma secretase subunit APH 1B antibody

Presenilin stabilisation factor like antibody

PRO1328 antibody

PSFL antibody

TAAV 688 antibody

General Information

Product

Insulin degrading enzyme Antibody

Verified Applications

ELISA, IP WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Insulin-degrading enzyme protein.

Accession #

GenBank: EAW50092.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

UPI00002289E9

Overview

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Molecular Function

ATPase activity; Ubiquitin Binding; Zinc ion binding; Insulin binding; Hydrolase; Metalloprotease; Protease

Subcellular Location

Cytoplasm; Cell membrane; Secreted

Structure

Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.

Alternative Nomenclature

Abeta-degrading protease antibody

FLJ35968 antibody

Ide antibody

insulin protease antibody

Insulin-degrading enzyme antibody

insulinase antibody

insulysin antibody

General Information

Product

FXIIIA Antibody

Description

Affinity Purified Blood coagulation factor XIII a subunit Antibody Multi-epitope

Verified Applications

CM, ELISA, ICC, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Multi-epitope synthetic peptides were used: amino acid range 1-50 and 700-732.  A mixture of synthetic peptides used for FXIIIA-101AP and FXIIIA-112AP.

Accession #

GenBank: AAA52415.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P00488

Overview

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Molecular Function

Metal ion binding; Protein-glutamine gamma-glutamyltransferase activity

Subcellular Location

Cytoplasm. Secreted

Structure

Tetramer of two A chains and two B chains.

Alternative Nomenclature

Coagulation factor XIII A chain antibody

F13A antibody

Factor XIIIA antibody

Fibrin stabilizing factor, A subunit antibody

Fibrinoligase antibody

FSF, A subunit antibody

TGase antibody

Transglutaminase A chain antibody

Transglutaminase. plasma antibody

General Information

Product

CD10 Antibody

Description

Affinity Purified Neprilysin Antibody Multi-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Multi-epitope synthetic peptides were used. A mixture of synthetic peptide taken within amino acid regions: 100-150, 200-250, 360-410, 450-500 and 700-750 on human Neprilysin protein.

Accession #

NCBI: NP_009218

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.72-0.78 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Multi-epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry

1:250

Immunoprecipitation

1:250

Western Blot

1:500

Protein

Uniprot #

P08473

Overview

Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. angiotensin maturation; cellular response to UV; replicative senescence

Molecular Function

Hydrolase, Metalloprotease, Protease

Subcellular Location

Cell membrane, Membrane

Expression

Adipose tissue; duodenum; kidney; small intestine

Structure

Belongs to the peptidase M13 family

Alternative Nomenclature

Atriopeptidase antibody

CALLA antibody

CD10 antibody

Common acute lymphocytic leukemia antigen antibody

DKFZp686O16152 antibody

EC 3.4.24.11 antibody

Enkephalinase antibody

EPN antibody

gp100 antibody

Membrane metallo endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10) antibody

Membrane metallo endopeptidase antibody

MGC126681 antibody

MGC126707 antibody

MME antibody

NEP antibody

Neprilysin antibody

Neutral endopeptidase antibody

SFE antibody

Skin fibroblast elastase antibody