General Information
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Product
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PACAP Peptide
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Description
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Antigenic Blocking Peptide Pituitary adenylate cyclase-activating polypeptide
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Verified Applications
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Immunodepletion, Immunocompetition
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Immunogen
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Synthetic peptide taken within amino acid region 125-176 on human Pituitary adenylate cyclase-activating polypeptide protein.
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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P18509
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Overview
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Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells.
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Molecular Function
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neuropeptide hormone activity
peptide hormone receptor binding
pituitary adenylate cyclase activating polypeptide activity
pituitary adenylate cyclase-activating polypeptide receptor binding
receptor binding
signal transducer activity, downstream of receptor
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Subcellular Location
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Secreted
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Expression
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Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
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Structure
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Belongs to the glucagon family.
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Alternative Nomenclature
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adenylate cyclase activating polypeptide 1 (pituitary) antibody
PACAP antibody
PACAP-related peptide antibody
Pituitary adenylate cyclase-activating polypeptide 27 antibody
Pituitary adenylate cyclase-activating polypeptide 38 antibody
Pituitary adenylate cyclase-activating polypeptide antibody
prepro-PACAP antibody
PRP-48 antibody
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