General Information
|
|
Product
|
HIPK2 Peptide
|
Description
|
Antigenic Blocking Peptide Homeodomain-interacting protein kinase 2 Antibody
|
Verified Applications
|
Immunodepletion, Immunocompetition
|
Peptide Description
|
Synthetic peptide taken within amino acid region 1150-1198 on human Homeodomain-interacting protein kinase 2 protein.
|
Physical Properties
|
|
Quantity
|
250 µg
|
Volume
|
100 µl
|
Form
|
Antigenic Blocking Peptide
|
Purification Method
|
Immobilized antigen affinity chromatography
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
Competition/Depletion assay
|
Refer to competition assay protocol
|
Protein
|
Uniprot #
|
Q9H2X6
|
Overview
|
Serine/threonine-protein kinase involved in transcription regulation, p53/TP53-mediated cellular apoptosis and regulation of the cell cycle. Acts as a corepressor of several transcription factors, including SMAD1 and POU4F1/Brn3a and probably NK homeodomain transcription factors. Phosphorylates PDX1, ATF1, PML, p53/TP53, CREB1, CTBP1, CBX4, RUNX1, EP300, CTNNB1, HMGA1 and ZBTB4. Inhibits cell growth and promotes apoptosis through the activation of p53/TP53 both at the transcription level and at the protein level (by phosphorylation and indirect acetylation). The phosphorylation of p53/TP53 may be mediated by a p53/TP53-HIPK2-AXIN1 complex. Involved in the response to hypoxia by acting as a transcriptional co-suppressor of HIF1A.
|
Molecular Function
|
ATP binding
protein kinase activity
protein serine/threonine kinase activity
RNA polymerase II activating transcription factor binding
RNA polymerase II transcription coactivator activity
SMAD binding
transcription corepressor activity
virion binding
|
Subcellular Location
|
Nucleus, PML body, Cytoplasm
|
Expression
|
Highly expressed in heart, muscle and kidney. Weakly expressed in a ubiquitous way. Down-regulated in several thyroid and breast tumors.
|
Alternative Nomenclature
|
HIPK 2 antibody
Homeodomain interacting protein kinase 2 antibody
Nbak1 antibody
Nuclear body-associated kinase 1 antibody
PRO0593 antibody
Sialophorin tail-associated nuclear serine/threonine-protein kinase antibody
Stank antibody
|
|
|