General Information
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Product
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IP3 receptorPeptide
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Description
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Antigenic Blocking Peptide Inositol 1,4,5-trisphosphate receptor type isoform 1
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic peptide
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Accession #
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NCBI: NP_001093422.2
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q14643
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Overview
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Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
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Molecular Function
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Calcium channel, Ion channel, Ligand-gated ion channel, Receptor
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Subcellular Location
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Endoplasmic reticulum membrane; Multi-pass membrane protein
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Expression
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Widely expressed
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Structure
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Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channe
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Alternative Nomenclature
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5-trisphosphate receptor antibody
DKFZp313N1434 antibody
inositol 1 4 5 triphosphate receptor type 1 antibody
Inositol 1 antibody
InsP3R1 antibody
IP3 antibody
IP3 receptor antibody
IP3R1 antibody
ITPR 1 antibody
SCA15 antibody
SCA16 antibody
SCA29 antibody
Type 1 inositol 1 4 5 trisphosphate receptor antibody
Type 1 inositol 1 antibody
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