General Information |
|
Product |
OGT1 Peptide |
Description |
Antigenic Blocking Peptide O-linked N-acetylglucosamine transferase Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid region 980-1030 on human O-linked N-acetylglucosamine transferase protein. |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity. |
Molecular Function |
Chromatin regulator, Glycosyltransferase, Transferase |
Subcellular Location |
Cell membrane, Cytoplasm, Membrane, Mitochondrion, Nucleus |
Expression |
Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver. |
Structure |
The TPR repeat domain is required for substrate binding and oligomerization. |
Alternative Nomenclature |
GlcNAc transferase HRNT1 O GlcNAc O GlcNAc transferase p110 subunit O linked N acetylglucosamine (GlcNAc) transferase (UDP N acetylglucosamine:polypeptide N acetylglucosaminyl transferase) UDP N acetylglucosamine peptide N UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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OGT1-101AP | |||
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OGT1-BIOTIN | |||
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OGT1-FITC | |||
|
PC-OGT1 | |||
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