General Information |
|
Product |
THAP1 Peptide |
Description |
Antigenic Blocking Peptide THAP domain-containing protein 1 Antibody |
Verified Applications |
Immunodepletion, Immunocompetition |
Species Cross Reactivity |
Human; Predicted: Mouse, Rat |
Peptide Description |
Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1. |
Accession # |
GenBank: CAG33537 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. |
Molecular Function |
Identical protein binding, Sequence-specific DNA binding, Zinc ion binding |
Subcellular Location |
Nucleus > nucleoplasm, PML body |
Expression |
Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta. |
Structure |
Belongs to the THAP1 family. |
Alternative Nomenclature |
Nuclear proapoptotic factor antibody THAP 1 antibody THAP domain containing apoptosis associated protein 1 antibody THAP domain containing protein 1 antibody THAP domain protein 1 antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
THAP1-101AP | |||
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THAP1-BIOTIN | |||
|
THAP1-FITC | |||
|
PC-THAP1 | |||
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