General Information |
|
Product |
Phospho-TICAM2 Peptide |
Description |
Antigenic Blocking Peptide Phosphorylated TRIF-related adapter molecule Antibody |
Verified Applications |
Immunocompeition, Immunodepletion |
Peptide Description |
Phosphorylated synthetic peptide corresponding to unique amino acid sequences on TRIF-related adapter molecule protein. |
Accession # |
GenBank: AAO74498.1 |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. |
Molecular Function |
phospholipid binding, signal transducer activity |
Subcellular Location |
Isoform 1 : Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane, Isoform 2 : Endoplasmic reticulum. Early endosome membrane. Late endosome membrane |
Expression |
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). |
Structure |
Homodimer. Interacts with TLR4, TICAM1, IRF3 and IRF7 in response to LPS. Interacts with IL1R1, IL1RAP, IRAK2, IRAK3 and TRAF6. Interacts with protein kinase-inactive mutants of IRAK1 and IRAK4. Isoform 1 interacts with isoform 2; the interaction occurs in late endosomes and dirupts the interaction between isoform 1 and TICAM1. Interacts with MYD88; the interaction decreases after IL-18 stimulation in time-dependent manner. Interacts with IL18R1 and IL8RAP. |
Alternative Nomenclature |
Putative NF-kappa-B-activating protein 502 antibody TIR containing adapter molecule 2 antibody TIR domain containing adaptor protein antibody TIRAP3 antibody TIRP antibody Toll-like receptor adaptor protein 3 antibody Toll/interleukin-1 receptor domain-containing protein antibody TRAM antibody TRIF-related adapter molecule antibody |
Protein information supplied by UniProt
FabGennix Phospho-TRIF adapter molecule Antibody has been used in 5 Publications |
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Majumdar, Tanmay, et al. "Tryptophan-kynurenine pathway attenuates β-catenin-dependent pro-parasitic role of STING-TICAM2-IRF3-IDO1 signalosome in Toxoplasma gondii infection." Cell Death & Disease 10.3 (2019). PMID30770800
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Immunoprecipitation, Western Blot; Human |
Iampietro, WCtrial et al. "Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection." PLoS pathogens 13.5 (2017). PMID28542576
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Western Blot; Human |
McGettrick, Anne F. et al. “Trif-Related Adapter Molecule Is Phosphorylated by PKC? During Toll-Like Receptor 4 Signaling.” Proceedings of the National Academy of Sciences of the United States of America 103.24 (2006): 9196–9201. PMC1482589
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Western Blot; Human |
Fischer, Hans et al. “Pathogen Specific, IRF3-Dependent Signaling and Innate Resistance to Human Kidney Infection.” Ed. Frederick M. Ausubel.PLoS Pathogens 6.9 (2010): e1001109. PMC2944801
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Western Blot; Human, Mouse |
Keck, Simone, et al. "Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells." The Journal of Immunology 186.9 (2011): 5478-5488. PMID21441453
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Western Blot; Mouse |
Publishing research using PTRAM-140AP? Please let us know, we can cite the reference in this WordCleaner
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