General Information
|
|
Product
|
GADD34 Positive Control
|
Description
|
Western Blot Positive Control Growth arrest and DNA damage-inducible protein GADD34
|
Verified Applications
|
WB
|
Immunogen
|
Purified Protein
|
Physical Properties
|
|
Quantity
|
5 Applications
|
Volume
|
Inquire
|
Form
|
Western Blot Positive Control
|
Storage
|
-20⁰C for long term storage
|
Application Protocol
|
|
Western Blot
|
1:500
|
Protein
|
|
Uniprot #
|
O75807
|
Overview
|
Recruits serine/threonine-protein phosphatase PP1 to dephosphorylate translation initation factor eIF2A/EIF2S1. This reverses shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress.
|
Molecular Function
|
Apoptosis; Stress Response; Translation regulation
|
Subcellular Location
|
Endoplasmic Reticulum membrane; Peripheral membrane protein; Cytoplasmic side; Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic Side
|
Expression
|
induced by methyl methanesulfonate and ionizing irradiation. Apoptosis is induced by interluekin 24 in melanoma cells
|
Structure
|
belongs to PPP1R15 family.
|
Alternative Nomenclature
|
Apoptosis associated protein antibody
GADD 34 antibody
Growth arrest and DNA-damage-inducible 34 antibody
Myeloid differentiation primary response protein MyD116 homolog antibody
PPP1R15A antibody
Protein phosphatase 1 regulatory (inhibitor) subunit 15A antibody
|