General Information
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Product
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TDRD1 Antibody
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Description
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Affinity Purified Tudor domain-containing protein 1 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 570-605 on TDRD1 protein.
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Accession #
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Gen Bank: BAG65177.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.52-0.53 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunohistochemistry |
1:100 |
Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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Q9BXT4
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Overview
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Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage.
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Molecular Function
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metal ion binding
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Subcellular Location
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cytoplasm (Note: Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body)
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Expression
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Testis and ovary specific. Also expressed in several cancers.
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Alternative Nomenclature
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Cancer/testis antigen 41.1 antibody
CT41.1 antibody
FLJ21082 antibody
MTR 1 antibody
Tudor domain containing protein 1 antibody
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