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General Information
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Product
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Presenilin 2 Antibody Affinity Purified
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Description
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Affinity Purified Presenilin-2 isoform 1 Antibody N-epitope
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Verified Applications
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ELISA, IMM, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein.
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Accession #
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NCBI: NP_036618
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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1.00-1.25 µg/µl in antibody stabilization buffer
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Determinant
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N-epitope
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunoprecipitation
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1:150
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Western Blot
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1:500
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Protein
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Uniprot #
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P49810
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Overview
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Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.
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Molecular Function
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Hydrolase, Protease, aspartic-type endopeptidase activity
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Subcellular Location
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Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
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Expression
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Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
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Structure
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Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a
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Alternative Nomenclature
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AD 3LP antibody
AD 4 antibody
AD 5 antibody
Alzheimer disease 4 antibody
CMD1V antibody
E5 1 antibody
Presenilin 2 (Alzheimer disease 4) antibody
PS2 antibody
PSEN 2 antibody
STM2 antibody
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Presenilin 2 Antibody FITC
Presenilin 2 Antibody BIOTIN
Presenilin 2 Blocking Peptide
Presenilin 2 Positive Control
