General Information

Product

C1orf146 Antibody

Description

Affinity Purified Chromosome 1 open reading frame 146 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-180 on human C1orf146 protein.

Accession #

NCBI:  NP_001012425

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q5VVC0

Overview

Uncharacterized protein C1orf146

Alternative Nomenclature

C1orf146 antibody

CA146_HUMAN antibody

Chromosome 1 open reading frame 146 antibody

RP11-163M2.4 antibody

Uncharacterized protein C1orf146 antibody

General Information

Product

Insulin degrading enzyme Antibody

Verified Applications

ELISA, IP WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human Insulin-degrading enzyme protein.

Accession #

GenBank: EAW50092.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

UPI00002289E9

Overview

Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Molecular Function

ATPase activity; Ubiquitin Binding; Zinc ion binding; Insulin binding; Hydrolase; Metalloprotease; Protease

Subcellular Location

Cytoplasm; Cell membrane; Secreted

Structure

Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.

Alternative Nomenclature

Abeta-degrading protease antibody

FLJ35968 antibody

Ide antibody

insulin protease antibody

Insulin-degrading enzyme antibody

insulinase antibody

insulysin antibody

General Information

Product

ENPP2 Antibody

Description

Affinity Purified ectonucleotide pyrophosphatase/phosphodiesterase 2 (Autotaxin) Antibody C-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 778-818 on human Ectonucleotide pyrophosphatase/phosphodiesterase 2 (autotaxin) protein.

Accession #

GenBank: EAW91988.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

Dot Blot

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

UPI0000EE3297

Overview

Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor.

Molecular Function

alkylglycerophosphoethanolamine phosphodiesterase activity; calcium ion binding; hydrolase activity; lysophospholipase activity; nucleic acid binding; nucleotide diphosphatase activity; phosphodiesterase I activity; polysaccharide binding; scavenger receptor activity; transcription factor binding; zinc ion binding

Subcellular Location

Secreted

Expression

Predominantly expressed in brain, placenta, ovary, and small intestine. Expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. Expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. Not detected in leukocytes. Isoform 1 is more highly expressed in peripheral tissues than in the central nervous system (CNS). Adipocytes only express isoform 1. Isoform 3 is more highly expressed in the brain than in peripheral tissues.

Structure

Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.

Contains 2 SMB (somatomedin-B) domains.

Alternative Nomenclature

ATX antibody

ATX X antibody

Autotaxin antibody

Autotaxin t antibody

Ectonucleotide pyrophosphatase/phosphodiesterase 2 antibody

Enpp2 antibody

Extracellular lysophospholipase D antibody

FLJ26803 antibody

LysoPLD antibody

NPP2 antibody

PD IALPHA antibody

PDNP2 antibody

Phosphodiesterase I alpha antibody

Plasma lysophospholipase D antibody

General Information

Product

Noelin Antibody Affinity Purified

Description

Affinity Purified Noelin isoform a precursor Antibody C-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

C-epitope synthetic peptide taken within amino acid region 130-230 on Noelin-1 protein.

Accession #

NCBI: NP_062371.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8R357

Molecular Function

beta-amyloid binding

Subcellular Location

extracellular space

Alternative Nomenclature

AMY antibody

NEUROBLASTOMA PROTEIN antibody

Neuronal olfactomedin-related ER localized protein antibody

Noe1 antibody

Noelin antibody

OlfA antibody

Olfactomedin 1 antibody

Olfm1 antibody

Pancortin 1 antibody

General Information

Product

Noelin Antibody Affinity Purified

Description

Affinity Purified Noelin isoform a precursor Antibody N-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

N-epitope synthetic peptide taken within amino acid region 1-60 on Noelin-1 protein.

Accession #

NCBI: NP_062371.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q8R357

Molecular Function

beta-amyloid binding

Subcellular Location

extracellular space

Alternative Nomenclature

AMY antibody

NEUROBLASTOMA PROTEIN antibody

Neuronal olfactomedin-related ER localized protein antibody

Noe1 antibody

Noelin antibody

OlfA antibody

Olfactomedin 1 antibody

Olfm1 antibody

Pancortin antibody

General Information

Product

Mitofusin 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 543-593 on human Mitofusin 2 protein.

Accession #

NCBI:  NP_055689

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunohistochemistry

1:100

Western Blot

1:500

Protein

Uniprot #

O95140

Overview

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

Molecular Function

Hydrolase; GTP-binding, Nucleotide binding

Subcellular Location

Mitochondrion outer membrane; Multi-pass membrane protein

Expression

Ubiquitous; expressed at low level. Highly expressed in heart and kidney.

Structure

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA famil. Mitofusin subfamily. Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Alternative Nomenclature

CMT2A antibody
CMT2A2 antibody
CPRP 1 antibody
EC 3.6.5.- antibody
Fzo antibody
HSG antibody
hyperplasia suppressor gene antibody
Hypertension related protein 1 antibody
KIAA0214 antibody
MARF antibody
MFN 2 antibody

Mitochondrial assembly regulatory factor antibody
Mitofusin-2 antibody

Transmembrane GTPase MFN2 antibody

General Information

Product

ORP150 Antibody

Description

Affinity Purified Hypoxia up regulated 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 950-999 on human Hypoxia up regulated 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9Y4L1

Overview

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Molecular Function

ATP binding; chaperone binding

Subcellular Location

Endoplasmic reticulum lumen

Expression

Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

Structure

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the heat shock protein 70 family.

Alternative Nomenclature

150 kDa oxygen regulated protein antibody

170 kDa glucose regulated protein antibody

DKFZp686N08236 antibody

FLJ94899 antibody

FLJ97572 antibody

glucose regulated protein 170 antibody

Grp 170 antibody

Grp170 antibody

HSP 12A antibody

HSP12A antibody

Hyou1 antibody

Hypoxia up regulated 1 antibody

Orp 150 antibody

Orp150 antibody

oxygen regulated protein (150kD) antibody

General Information

Product

ALDH1A1 Antibody

Description

Affinity Purified Aldehyde Dehydrogenase family 1 member A1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 441-491 on rat retinal dehydrogenase 1 protein.

Accession #

NCBI:  NP_071852

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P51647

Overview

Is capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal.

Molecular Function

Oxidoreductase

Subcellular Location

Cytoplasm

Expression

Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.

Structure

Belongs to the aldehyde dehydrogenase family.

Alternative Nomenclature

Acetaldehyde dehydrogenase 1 antibody

AHD2 antibody

ALDC antibody

Aldehyde dehydrogenase 1 family member A1 antibody

Aldehyde dehydrogenase 1 soluble antibody

Aldehyde dehydrogenase 1A1 antibody

Aldehyde dehydrogenase antibody

Aldehyde dehydrogenase cytosolic antibody

Aldehyde dehydrogenase liver cytosolic antibody

ALDH 1 antibody

ALDH 1A1 antibody

ALDH class 1 antibody

ALDH, liver cytosolic antibody

ALDH-E1 antibody

ALDH1 antibody

ALDH11 antibody

ALDH1A1 antibody

ALHDII antibody

epididymis luminal protein 12 antibody

epididymis luminal protein 9 antibody

epididymis secretory sperm binding protein Li 53e antibody

HEL-S-53e antibody

MGC2318 antibody

PUMB1 antibody

RALDH 1 antibody

Retinal dehydrogenase 1 antibody

General Information

Product

ATG16L1 Antibody

Description

Affinity Purified Autophagy-related protein 16-1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Predicted: Human

Immunogen

Synthetic peptide taken within amino acid region 560-610 on human Autophagy-related protein 16-1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q676U5

Overview

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.

Molecular Function

Identical protein binding, Ubiquitin-like protein transferase activity

Subcellular Location

Cytoplasm, Preautophagosomal structure membrane, Peripheral membrane protein

Structure

Homooligomer. Interacts with WIPI2, FIP200 and ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). Interacts with RAB33B. Interacts with TMEM

Alternative Nomenclature

APG16 like 1 antibody

APG16L antibody

APG16L beta antibody

ATG16 autophagy related 16 like 1 antibody

ATG16A antibody

ATG16L antibody

Autophagy related protein 16 1 antibody

IBD10 antibody

WD repeat domain 30 antibody

WDR30 antibody

General Information

Product

Calcyon Antibody

Description

Affinity Purified Neuron-specific vesicular protein Calcyon Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Predicted: Human

Immunogen

Synthetic peptide taken within amino acid region 1-50 on rat Calcyon protein.

Accession #

NCBI:  NP_620270

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P58821

Overview

Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

Molecular Function

Clathrin light chain binding, dopamine receptor binding, protein complex binding

Subcellular Location

Cytoplasmic vesicle membrane, cell membrane, Single-pass membrane protein

Alternative Nomenclature

CALCYON antibody,

Caly antibody,

CALY_HUMAN antibody,

D1 dopamine receptor interacting protein antibody,

Drd1ip antibody,

Neuron specific vesicular protein calcyon antibody,

NSG3 antibody