General Information |
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Product |
BMP2 Positive Control |
Description |
Western Blot Positive Control Bone morphogenetic Protein 2 Antibody |
Verified Applications |
WB |
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Quantity |
5 Applications |
Volume |
Inquire |
Concentration |
The concentration of the sample is empirically set so that 20 µl per lane in Western and blotted with corresponding affinity purified antibody will give a clean band with a high signal to noise ratio on the gel. |
Form |
Western Blot Positive Control |
Storage |
-20?C for long term storage |
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Uniprot # |
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Overview |
Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451). |
Molecular Function |
BMP receptor binding co-receptor binding cytokine activity growth factor activity phosphatase activator activity retinol dehydrogenase activity signaling receptor binding SMAD binding |
Subcellular Location |
Secreted |
Expression |
Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine. |
Structure |
Belongs to the TGF-beta family. |
Alternative Nomenclature |
BDA2 antibod BMP 2 antibody BMP 2A antibody BMP-2 antibody BMP-2A antibody Bmp2 antibody BMP2_HUMAN antibody BMP2A antibody Bone morphogenetic protein 2 antibody Bone morphogenetic protein 2A antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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BMP-212AP | |||
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BMP-212-BIOTIN | |||
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BMP-212-FITC | |||
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P-BMP-212 | |||
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