General Information |
|
Product |
Bestrophin 3 Antibody BIOTIN |
Verified Applications |
CM, ELISA, IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Mouse, Rat |
Immunogen |
Synthetic peptide taken within the last 50 amino acids from the C-terminus of rat Bestrophin-3 protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:200 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:200 |
Immunofluorescence |
1:200 |
Immunohistochemistry |
1:200 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500-1:1,000 |
|
|
Uniprot # |
|
Overview |
Forms calcium-sensitive chloride channels. Permeable to bicarbonate. |
Molecular Function |
Ion transport; Calcium, Chloride. |
Subcellular Location |
Cell membrane; Multi-pass membrane protein. |
Expression |
Skeletal muscle and weakly in brain, spinal cord, bone marrow and retina. |
Structure |
Belongs to bestrophin Family |
Alternative Nomenclature |
BEST 3 antibody Bestrophin3 antibody MGC13168 antibody MGC40411 antibody Vitelliform macular dystrophy 2-like protein 3 antibody VMD2L3 antibody |
Protein information supplied by UniProt
Fabgennix Bestrophin 3 Antibody has been used in 6 Publications |
|
Golubinskaya, V., et al. "Bestrophin‐3 is differently expressed in normal and injured mouse glomerular podocytes." Acta Physiologica (2015). PMID25912364
|
Electron Microscopy, Immunodepletion, Western Blot; Mouse
|
Jiang, Lei, et al. "Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells." Apoptosis 18.5 (2013): 556-565. PMID23468120
|
Western Blot; Rat |
Lee, Wing-Kee, et al. "ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823.10 (2012): 1864-1876. PMID22705154
|
Immunofluorescence, Western Blot; Rat |
Wang, Mi, et al. "Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation." Circulation 125.5 (2012): 697-707. PMID22215857
|
Western Blot; Rat |
Broegger, Torbjoern, et al. "Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries." Cardiovascular research 91.4 (2011): 685-693. PMID21498420
|
Immunofluorescence, Immunohistochemistry, Western Blot; Rat
|
Matchkov, Vladimir V., et al. "Bestrophin-3 (Vitelliform Macular Dystrophy 2–Like 3 Protein) Is Essential for the cGMP-Dependent Calcium-Activated Chloride Conductance in Vascular Smooth Muscle Cells." Circulation research 103.8 (2008): 864-872. PMID18776041
|
Western Blot; Rat |
Publishing research using BEST-301AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-BEST3.1 | |||
|
BEST-301AP | |||
|
BEST3.1-FITC | |||
|
PC-BEST3 | |||
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