General Information |
|
Product |
WWOX3 Antibody BIOTIN |
Description |
BIOTIN-Conjugated Oxidoreductase Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 250-300 on human WWOXdelta5-8 protein. |
Accession # |
GenBank: AAA21465.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-0.75 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000-1:100,000 |
ELISA |
1:10,000-1:100,000 |
Immunohistochemistry | 1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
Molecular Function |
Coenzyme binding; protein dimerization activity; cofactor binding; |
Subcellular Location |
Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus |
Expression |
Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
Structure |
Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2. Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN. Interacts with TNK2. Interacts with TMEM207. |
Alternative Nomenclature |
D16S432E antibody FOR antibody FRA16D antibody Fragile site FRA16D oxidoreductase antibody HHCMA56 antibody PRO0128 antibody SCAR12 antibody SDR41C1 antibody short chain dehydrogenase/reductase family 41C member 1 antibody WW domain-containing oxidoreductase antibody wwox antibody WWOX_HUMAN antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-WWOX3 | |||
|
WWOX3-301AP | |||
|
WWOX3-FITC | |||
|
PC-WWOX3 | |||
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