General Information |
|
Product |
Epac2 Antibody FITC-Conjugated |
Description |
FITC-Conjugated Rap Guanine Nucleotide Exchange Factor 3 Antibody |
Verified Applications |
CM, ELISA, ICC/IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Horse, Human, Mouse, Rabbit, Rat |
Immunogen |
Synthetic peptide corresponding to amino acids 743-762 of Epac2 protein.
CPREQFDSLTPLPEQEGPT |
Specificity | This antibody does not cross react with other Epac family proteins. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.67 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
Confocal Microscopy |
1:200 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:200 |
Immunofluorescence |
1:200 |
Immunohistochemistry |
1:200 |
Immunoprecipitation | 1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. |
Molecular Function |
Guanine-nucleotide releasing factor |
Subcellular Location |
Cytoplasm; Membrane; Peripheral membrane protein |
Structure |
Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A. |
Alternative Nomenclature |
CAMP GEFII antibody cAMP regulated guanine nucleotide exchange factor II antibody CGEF2 antibody Epac 2 antibody Exchange protein directly activated by cAMP 2 antibody Nbla00496 antibody Putative protein product of Nbla00496 antibody Rap guanine nucleotide exchange factor (GEF) 4 antibody RAPGEF 4 antibody |
Protein information supplied by UniProt
Fabgennix Epac2 Antibody has been used in 1 Publication |
|
McPartlin, L.A., P.E. Visconti, and S.J. Bedford-Guaus. “Guanine-Nucleotide Exchange Factors (RAPGEF3/RAPGEF4) Induce Sperm Membrane Depolarization and Acrosomal Exocytosis in Capacitated Stallion Sperm.”Biology of Reproduction 85.1 (2011): 179–188. PMC3123385
|
Confocal Microscopy, Immunofluorescence, Western Blot; Horse, Mouse |
Publishing research using EPAC-201AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
---|---|---|---|---|
|
EPAC-201AP | |||
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P-EPAC2 | |||
|
EPAC2-BIOTIN | |||
|
PC-EPAC2 | |||
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(c) FabGennix International Inc.