General Information |
|
Product |
TLR4 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Toll-like receptor 4 Antibody |
Verified Applications |
ELISA, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human |
Immunogen |
Synthetic peptide taken within amino acid region 970-1000 on human TLR4 protein. |
Accession # |
GenBank: AAF05316.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.66-0.8 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:20,000 |
ELISA |
1:20,000 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. |
Molecular Function |
Receptor, lipopolysaccharide binding, transmembrane signaling receptor activity |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. |
Structure |
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via the |
Alternative Nomenclature |
ARMD10 antibody CD284 antibody Homolog of Drosophila toll antibody hToll antibody TLR 4 antibody Toll (Drosophila) homolog antibody TOLL antibody Toll Endotoxin Hyporesponsiveness antibody Toll like receptor 4 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-TLR4 | |||
|
TLR-401AP | |||
|
TLR4-FITC | |||
|
PC-TLR4 | |||
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