General Information |
|
Product |
C4a Antibody FITC-Conjugated |
Description |
FITC-Conjugated Complement C4-A Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey, 80% homology with rat |
Immunogen |
Synthetic peptide taken within amino acid region 1220-1270 on human complement C4-A preprotein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.6 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunohistochemistry | 1:100 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens. Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. |
Molecular Function |
Complement component C1q binding; Endopeptidase inhibitor activity |
Subcellular Location |
Secreted |
Expression |
Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. |
Structure |
Contains 1 anaphylatoxin-like domain. Contains 1 NTR domain. |
Alternative Nomenclature |
Acidic C4 antibody Acidic complement C4 antibody Basic C4 antibody Basic complement C4 antibody C3 and PZP like alpha 2 macroglobulin domain containing protein 2 antibody C4 Anaphylatoxin antibody C4 complement C4d region antibody C4 propeptide antibody C4A antibody CH antibody Chido form of C4 antibody CO4 antibody Complement C4 A antibody Complement C4 gamma chain antibody Complement component 4A antibody Complement component 4A preproprotein antibody Complement component 4B (Childo blood group) antibody CPAMD2 antibody CPAMD3 antibody RG antibody Rodgers Form Of C4 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
C4A-101AP | |||
|
P-C4A | |||
|
C4A-BIOTIN | |||
|
PC-C4A | |||
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