General Information |
|
Product |
Prominin 1 Peptide |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
Synthetic peptide taken within amino acid regions 700-730 on CD133 protein |
Accession # |
NCBI: XP_006714037.1 |
|
|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
|
|
Competition/Depletion assay |
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|
|
Uniprot # |
|
Overview |
May play a role in cell differentiation, proliferation and apoptosis (PubMed:24556617). Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner (PubMed:20818439). |
Molecular Function |
Actinin binding; Cadherin binding |
Subcellular Location |
Apical cell membrane; Multi-pass membrane protein; microvillus membrane; cilium; photoreceptor outer segment; Endoplasmic reticulum-Golgi intermediate compartment |
Expression |
Isoform 1 is selectively expressed on CD34 hematopoietic stem and progenitor cells in adult and fetal bone marrow, fetal liver, cord blood and adult peripheral blood. Isoform 1 is not detected on other blood cells. Isoform 1 is also expressed in a number of non-lymphoid tissues including retina, pancreas, placenta, kidney, liver, lung, brain and heart. Found in saliva within small membrane particles. Isoform 2 is predominantly expressed in fetal liver, low in bone marrow, and barely detectable in peripheral blood. Isoform 2 is expressed on hematopoietic stem cells and in epidermal basal cells (at protein level). Expressed in adult retina by rod and cone photoreceptor cells (at protein level). |
Structure |
Interacts with CDHR1 and with actin filaments. Interacts with NAT8 and NAT8B. |
Alternative Nomenclature |
AC133 antibody CD133 antibody CORD12 antibody Hematopoietic stem cell antigen antibody MCDR2 antibody MSTP061 antibody RP41 antibody STGD4 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
PROM-101AP | |||
|
PROM.101-FITC | |||
|
PROM.101-BIOTIN | |||
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PC-PROM | |||
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