General Information
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Product
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PARD6B Antibody
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Description
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Affinity Purified Partitioning Defective 6 homolog beta Antibody
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Verified Applications
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ELISA, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Mouse, Rat
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Immunogen
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Synthetic peptide corresponding to amino acids within region 300-350 on human Partitioning Defective 6 homolog beta.
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5-1.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Purification Method
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Immobilized antigen affinity chromatography
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Clonality
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Polyclonal
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Storage
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-20C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunoprecipitation
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1:200
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Western Blot
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1:500-1:5,000
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Protein
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Uniprot #
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Q9BYG5
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Overview
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Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
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Molecular Function
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protein kinase C binding
Rho GTPase binding
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Subcellular Location
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Cell membrane, Cytoplasm
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Expression
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Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
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Structure
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The pseudo-CRIB domain together with the PDZ domain is required for the interaction with Rho small GTPases.
The PDZ domain mediates interaction with MPP5.
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Alternative Nomenclature
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OTTHUMP00000031269 antibody
PAR 6 beta antibody
Par 6 partitioning defective 6 homolog beta (C. elegans) antibody
PAR6B antibody
PARD6 beta antibody
PARD6B antibody
partitioning defective 6 homolog beta antibody
partitioning-defective protein 6, C. elegans, homolog of, beta antibody
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