General Information |
|
Product |
ASF1A Antibody FITC-Conjugated |
Description |
FITC-Conjugated Histone Chaperone ASF1A Antibody |
Verified Applications |
DB, ELISA, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 60-120 on human AF1A protein. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.58 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:4,000 |
ELISA |
1:4,000 |
Immunohistochemistry | 1:50-1:100 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly. Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with HIRA to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. |
Molecular Function |
Transcription regulation |
Subcellular Location |
Nucleus |
Structure |
Interacts with histone H3 (including both histone H3.1 and H3.3) and histone H4. Interacts with the CHAF1A, CHAF1B and RBBP4 subunits of the CAF-1 complex. Interacts with CABIN1, HAT1, HIRA, NASP, TAF1, TLK1, TLK2 and UBN1. Interacts with CDAN1. Found in cytosolic coplex with CDAN1, ASF1B, IPO4 and histones H3.1 and H4. Interacts with CREBBP. |
Alternative Nomenclature |
Anti silencing function 1A antibody asf1a antibody CCG1-interacting factor A antibody CGI 98 antibody CIA antibody hAsf1 antibody hAsf1a antibody hCIA antibody Histone chaperone ASF1A antibody HSPC146 antibody Hypothetical protein FLJ22085 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
ASF1A-101AP | |||
|
P-ASF1A | |||
|
ASF1A-BIOTIN | |||
|
PC-ASF1A | |||
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