General Information

Product

Axl Antibody

Description

Affinity Purified AXL receptor tyrosine kinase UFO isoform 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 840-880 on mouse AXL protein. The peptide was post translationally modified to acheive proper orientation and antigenicity.

Accession #

NCBI:  NP_033491

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Western Blot

1:500

Protein

Uniprot #

Q00993

Overview

Receptor tyrosine kinase that transduces signals from the ECM into cytoplasm by binding growth factor GAS6. Regulates survival, proliferation, migration and differentiation.

Molecular Function

ATP-binding, Nucleotide binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase, Immunity Differentation and Innate Immunity.

Subcellular Location

Cell membrane; Single-pass type II membrane protein.

Expression

Developing tissues in late embryogenesis. In cells forming organ capsules as well as in connective tissue structures in adult.

Structure

Heterodimer and heterotetramer with ligand GAS6.

Alternative Nomenclature

Adhesion related kinase 

Ark 

Tyro7 

Tyrosine protein kinase receptor UFO 

General Information

Product

GPIP137 Antibody

Description

Affinity Purified Caprin-1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Caprin 1 protein.

Accession #

NCBI: NP_976240

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q14444

Overview

Involved in transport and translation of mRNAs of proteins involved in synaptic plasticity in neurons and cell proliferation and migration in multiple cell types.

Molecular Function

RNA-binding; Differentiation

Subcellular Location

Cytoplasm; Cell projection

Expression

Ubiquitous

Structure

May form homomultimers.  Binds with several mRNAs.  Directly interacts with G3BP1 in cytoplasmic RNA granules.

Alternative Nomenclature

Cell cycle-associated protein 1 antibody

GPI-anchored protein p137 antibody

M11S1 antibody

Membrane component chromosome 11 surface marker 1 antibody

RNA granule protein 105 antibody

General Information

Product

GLP2R Antibody

Description

Affinity Purified Glucagon like peptide 2 Receptor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 375-425 on human GLP2R protein.

Accession #

GenBank: AAH43390.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q86XI5

Overview

GPCR activity

Subcellular Location

Cell membrane; Membrane

Alternative Nomenclature

GLP 2 R antibody

GLP 2 receptor antibody

GLP2R antibody

Glucagon-like peptide 2 receptor antibody

General Information

Product

IFI16 Antibody Affinity Purified

Description

Affinity Purified Gamma-interferon-inducible protein 16 isoform 1 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 140-190 on human IFI16 protein

Accession #

NCBI:  NP_001193496.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58-0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q16666

Overview

Binds double-stranded DNA. Binds preferentially to supercoiled DNA and cruciform DNA structures. Seems to be involved in transcriptional regulation. May function as a transcriptional repressor. Could have a role in the regulation of hematopoietic differentiation through activation of unknown target genes. Controls cellular proliferation by modulating the functions of cell cycle regulatory factors including p53/TP53 and the retinoblastoma protein.

Molecular Function

Core promoter binding, identical protein binding, transcription factor binding, double-standard DNA binding, poly(A) RNA binding

Subcellular Location

Nucleus, cytoplasm (Note: Cellular distribution is dependent on acetylation status of multipartite nuclear localization signal(NLS); NLS acetylation promotes cytoplasmic localization. Localizes in nucleus during human herbes simplex virus 1 infection)

Expression

Expressed in peripheral blood leukocytes, fibroblasts and lymphoid cells. Present in myeloid precursors (CD34+) and throughout monocyte development, but its expression is down-regulated in erythroid and polymorphonuclear precursor cells. Present in prosta

Alternative Nomenclature

IFI16 antibody

Gamma interferon inducible protein 16 antibody

Ifi204 antibody

IFNGIP1 antibody

interferon activated gene 204 antibody

Interferon gamma inducible protein 16 antibody

p204 antibody

PYHIN2 antibody

General Information

Product

mTOR Antibody Affinity Purified

Description

Affinity Purified Serine/threonine-protein kinase mTOR Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 430-480 on mTOR protein.

Accession #

NCBI:  NP_063971.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P42346

Overview

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Lysosome, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Alternative Nomenclature

FK506 binding protein 12 rapamycin associated protein 1 antibody

FKBP rapamycin associated protein antibody

FRAP1 antibody

FRAP2 antibody

mTOR antibody

RAFT1 antibody

Rapamycin target protein antibody

RAPT1 antibody

Serine/threonine-protein kinase mTOR antibody

General Information

Product

Phospho-ACK1 Antibody Antibodyd

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 250-300 on ACK1 protein. 

Accession #

GenBank: AAL55732.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-1.25 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

Dot Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P13749

Overview

Plays a role in presenting foreign antigens to the immune system.

Molecular Function

peptide antigen bonding

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Heterodimer of an alpha chain and a beta chain

Alternative Nomenclature

Acetate kinase 1 antibody

ACK 1 antibody

ACK antibody

Activated Cdc42 associated kinase 1 antibody

Activated p21cdc42Hs kinase antibody

FLJ44758 antibody

FLJ45547 antibody

p21cdc42Hs antibody

TNK 2 antibody

Tyrosine kinase non receptor 2 antibody

General Information

Product

Quiescine Q6 Antibody

Description

Affinity Purified Sulfhydryl oxidase 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human QSOX1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O00391

Overview

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.  May contribute to disulfide bond formation in a variety of secreted proteins.

Molecular Function

Oxidoreductase, flavin-linked sulfhydryl oxidase activity, protein disulfide isomerase activity

Subcellular Location

Isoform 1: Golgi apparatus membrane; Single plass membrane protein Isoform 2: Secreted > extracellular space

Expression

Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.

Structure

Monomer

Alternative Nomenclature

FLJ34858 antibody

hQSOX antibody

Human quiescin (Q6) mRNA, partial cds antibody

Q6 antibody

QSCN6 antibody

QSOX1 antibody

Quiescin Q6 antibody

Quiescin Q6 sulfhydryl oxidase 1 antibody

Skin sulfhydryl oxidase antibody

Sox antibody

Sulfhydryl oxidase 1 antibody

General Information

Product

ROCK1 Antibody

Description

Affinity Purified Rho-associated protein kinase 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Pig, Rat

Immunogen

Synthetic peptide taken within amino acid region spanning 850-900 on human ROCK1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.57 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q13464

Overview

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Golgi apparatus membrane; Peripheral membrane protein, Cell projection

Expression

Detected in blood platelets.

Structure

Homodimer. Interacts with RHOB, RHOC, MYLC2B and PTEN. Interacts with ITGB1BP1 (via N-terminus and PTB domain). Interacts with RHOA (activated by GTP), CHORDC1, DAPK3, GEM, JIP3, RHOE, PPP1R12A, PFN1, LIMK1, LIMK2 and TSG101. Interacts with FHOD1 in a Src-dependent manner.

Alternative Nomenclature

coiled-coil-containing protein kinase 1 antibody

NY REN 35 antigen antibody

p160 Rhoassociated coiled coil-forming protein kinase antibody

p160 ROCK1 antibody

PRO0435 antibody

Renal carcinoma antigen NY REN 35 antibody

Rho associated coiled coil containing protein kinase 1 antibody

Rho-alpha kinase antibody

Rho-associated protein kinase 1 antibody

Rok antibody

rokalpha antibody

General Information

Product

Septin 2 Antibody Affinity Purified

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 270-320 on human Septin-2 protein.

Accession #

Gen Bank:  AAH14455.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q15019

Overview

Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating effiecient vesicle transport, and by impeding MAP4 binding to tubulin. Required for progression through mitosis.

Molecular Function

Enzyme regulator activity

Subcellular Location

Cytoplasm, cytoskeleton, spindle, cleavage furrow, midbody, cell cortex, cilium membrane

Expression

Widely expressed. Up-regulated in liver cancer.

Alternative Nomenclature

DIFF6 antibody

KIAA0158 antibody

NEDD 5 antibody

Neural precursor cell expressed developmentally down regulated protein 5 antibody

Pnutl3 antibody

Protein NEDD5 antibody

septin 2 antibody

General Information

Product

Septin 3 Antibody Affinity Purified

Description

Affinity Purified Septin 3 Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 260-330 on SEPT3 protein.

Accession #

Gen Bank:  CAQ07552.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9UH03

Overview

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential).

Molecular Function

GTP binding

Subcellular Location

Cytoplasm, cell junction

Expression

Brain-specific

Alternative Nomenclature

bK250D10.3 antibody

MGC133218 antibody

Neuronal specific septin 3 antibody

SEP3 antibody

SEPT 3 antibody

Septin3 antibody