General Information
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Product
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Ephrin Receptor A7 Peptide
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Description
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Antigenic Blocking Peptide Ephrin type-A receptor 7 isoform 1 precursor Antibody
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic peptide corresponding taken within amino acid region 500-550 on human Ephrin type-A receptor 7 protein.
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Accession #
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NCBI: NP_004431
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q15375
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Overview
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Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity.
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Molecular Function
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Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
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Subcellular Location
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Cell membrane, Single-pass type 1 membrane protein
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Expression
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Widely Expressed
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Structure
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Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK1.
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Alternative Nomenclature
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Cek 11 antibody
Developmental kinase 1 antibody
EBK antibody
EHK3 antibody
EK11 antibody
Embryonic brain kinase antibody
Eph homology kinase 3 antibody
Eph receptor A7 antibody
EPH-like kinase 11 antibody
EphA7 antibody
Ephrin type-A receptor 7 antibody
hEK11 antibody
MDK 1 antibody
Receptor protein tyrosine kinase HEK 11 antibody
Tyrosine protein kinase receptor EHK 3 antibody
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