WDR5 Antibody

Product no.: WDR5-101AP

$285.00

Description

General Information
Product	WDR5 Antibody
Description	Affinity Purified WD repeat-containing protein 5 Antibody
Verified Applications	ChIP, ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Arabidopsis thaliana, Human, Monkey, Mouse, Rat Predicted: Chicken, Cow, Dog, Pig, Xenopus laevis, Zebrafish
Immunogen	Synthetic peptide: DVKTGKCLKTLPAHSDPV corresponding to amino acids 157-174 of Human WDR5 protein.
Accession #	NCBI: NP_060058.2
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.67 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunohistochemistry	1:100
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P61964
Overview	Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.
Molecular Function	Chromatin regulator
Subcellular Location	Nucleus
Structure	Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Alternative Nomenclature	2410008O07Rik antibody AA408785 antibody AA960360 antibody Big antibody BIG3 antibody BMP2 induced 3 kb gene protein antibody MGC114572 antibody OTTHUMP00000162494 antibody SWD3 Set1c WD40 repeat protein homolog antibody WD repeat-containing protein 5 antibody WD repeat-containing protein BIG-3 antibody WDR 5 antibody

Protein information supplied by UniProt