General Information |
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Product |
Eprhin Receptor A4 Peptide |
Description |
Antigenic Blocking Peptide Ephrin type-A receptor 4 Antibody |
Verified Applications |
Immunocompetition, Immunodepletion |
Peptide Description |
Synthetic Peptide |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Uniprot # |
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Overview |
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. |
Molecular Function |
ATP-binding, Nucleotide-binding |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Highest expression in the adult brain and retina and also detectable in kidney, lung, skeletal muscle and thymus. Not detected in heart and liver. |
Structure |
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (phosphorylated at position Tyr-602) with FYN. Interacts (via |
Alternative Nomenclature |
Cek 8 antibody EK8 antibody eph receptor a4 antibody EPH-like kinase 8 antibody EphA4 antibody Ephrin receptor Eph A4 antibody hEK8 antibody Receptor protein tyrosine kinase HEK 8 antibody Sek 1 antibody SEK antibody TYRO 1 protein tyrosine kinase antibody Tyrosine-protein kinase receptor SEK antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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EPHAR4-401AP | |||
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EPHAR4-FITC | |||
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EPHAR4-BIOTIN | |||
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PC-EPHAR4 | |||
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