General Information
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Product
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Dopamine D2 Receptor Antibody FITC
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Description
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FITC-Conjugated Dopamine Receptor subtype D2 Antibody
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Verified Applications
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CM, ELISA, ICC, IF, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Mouse, Rat
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Immunogen
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Synthetic peptide taken within amino acid region 150-200 on rat Dopamine Receptor D2 protein.
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Accession #
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GenBank: AAA41075.1
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.55µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20°C for long term storage
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Application Protocol
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ELISA
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1:50,000
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Immunocytochemistry
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1:200
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Immunofluorescence
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1:200
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Immunohistochemistry
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1:200
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Immunoprecipitation
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1:200
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Western Blot
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1:1,000-1:1,5000
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Protein
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Uniprot #
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Q6LDH7
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Overview
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Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
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Molecular Function
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Dopamine Binding; Potassium Channel Regulator activity; Identical Protein binding
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Subcellular Location
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Cell membrane; Multi-pass membrane protein
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Structure
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Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with GPRASP1, PPP1R9B and CLIC6 (By similarity). Interacts with CADPS and CADPS2. Interacts with ARRB2 (By similarity). Interacts with KCNA2 (By similarity). Interacts with GNAI1 (PubMed:17264214). Interacts with GNAI2 isoform sGi2, the interaction allows the creation of an intracellular pool of DRD2 that can be released to cell surface upon agonist stimulation. Interacts with HTR2A.
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Alternative Nomenclature
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D(2) dopamine receptor antibody
D2 dopamine receptor antibody
D2DR antibody
D2R antibody
Dopamine D2 receptor antibody
DRD2 antibody
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