General Information |
|
Product |
Presenilin 2 Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Presenilin-2 isoform 1 Antibody N-epitope |
Verified Applications |
ELISA, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey, Rat |
Immunogen |
Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein. |
Accession # |
NCBI: NP_036618 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
1.00-1.25 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
N-epitope |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. |
Molecular Function |
Hydrolase, Protease, aspartic-type endopeptidase activity |
Subcellular Location |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein |
Expression |
Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney. |
Structure |
Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase a |
Alternative Nomenclature |
AD 3LP antibody AD 4 antibody AD 5 antibody Alzheimer disease 4 antibody CMD1V antibody E5 1 antibody Presenilin 2 (Alzheimer disease 4) antibody PS2 antibody PSEN 2 antibody STM2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
P-PSEN2 | |||
|
PSEN-201AP | |||
|
PSEN2-FITC | |||
|
PC-PSEN2 | |||
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