General Information
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Product
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WDR5 Antibody FITC-Conjugated
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Description
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FITC-Conjugated WD repeat-containing protein 5 Antibody
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Verified Applications
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ChIP, ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Arabidopsis thaliana, Human, Monkey, Mouse, Rat
Predicted: Chicken, Cow, Dog, Pig, Xenopus laevis, Zebrafish
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Immunogen
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Synthetic peptide:
DVKTGKCLKTLPAHSDPV
corresponding to amino acids 157-174 of Human WDR5 protein.
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Accession #
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NCBI: NP_060058.2
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.67 µg/µl in antibody stabilization buffer
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Form
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FITC-Conjugated
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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DB
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1:10,000
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ELISA
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1:10,000
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Immunohistochemistry |
1:100 |
Immunoprecipitation |
1:200 |
Western Blot
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1:500
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Protein
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Uniprot #
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P61964
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Overview
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Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.
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Molecular Function
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Chromatin regulator
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Subcellular Location
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Nucleus
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Structure
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Interacts with PAXBP1; the interaction is direct and links a WDR5-containing histone methyltransferase complex to PAX7 and PAX3. Interacts with HCFC1. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
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Alternative Nomenclature
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2410008O07Rik antibody
AA408785 antibody
AA960360 antibody
Big antibody
BIG3 antibody
BMP2 induced 3 kb gene protein antibody
MGC114572 antibody
OTTHUMP00000162494 antibody
SWD3 Set1c WD40 repeat protein homolog antibody
WD repeat-containing protein 5 antibody
WD repeat-containing protein BIG-3 antibody
WDR 5 antibody
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