General Information |
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Product |
TLR4 Antibody Western Blot Positive Control |
Description |
Western Blot Positive Control Toll-like receptor 4 Antibody |
Verified Applications |
WB |
Immunogen |
Purified Protein |
Accession # |
GenBank: AAF05316.1 |
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Quantity |
5 Applications |
Volume |
Inquire |
Form |
Western Blot Positive Control |
Storage |
-20⁰C for long term storage |
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Western Blot |
1:500 |
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Uniprot # |
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Overview |
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. |
Molecular Function |
Receptor, lipopolysaccharide binding, transmembrane signaling receptor activity |
Subcellular Location |
Cell membrane; Single-pass type I membrane protein |
Expression |
Highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells. |
Structure |
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4. Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain. Interacts with MYD88 and TIRAP via the |
Alternative Nomenclature |
ARMD10 antibody CD284 antibody Homolog of Drosophila toll antibody hToll antibody TLR 4 antibody Toll (Drosophila) homolog antibody TOLL antibody Toll Endotoxin Hyporesponsiveness antibody Toll like receptor 4 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
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TLR-401AP | |||
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TLR4-FITC | |||
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P-TLR4 | |||
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TLR4-BIOTIN | |||
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