General Information |
|
Product |
TMEM16A Antibody FITC-Conjugated |
Description |
FITC-Conjugated Transmembrane protein 16A Antibody C-epitope |
Verified Applications |
ELISA, IMM, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human |
Immunogen |
Synthetic peptide taken within amino acid region 900-950 on human Transmembrane protein 16A. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.50 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. |
Molecular Function |
Chloride channel, Developmental protein, Ion channel |
Subcellular Location |
Cell membrane; Multi-pass membrane protein, Cytoplasm |
Expression |
Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles. |
Structure |
Homodimer. Interacts with CFTR (By similarity). |
Alternative Nomenclature |
ANO 1 antibody Anoctamin 1 antibody Anoctamin 1 calcium activated chloride channel antibody Ca2+ activated Cl- channel antibody Discovered on gastrointestinal stromal tumors protein 1 antibody DOG 1 antibody Membrane protein antibody Oral cancer overexpressed protein 2 antibody ORAOV 2 antibody TAOS2 antibody Transmembrane protein 16A antibody Tumor-amplified and overexpressed sequence 2 antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
TMEM16-112AP | |||
|
P-TMEM16.112 | |||
|
TMEM16.112-BIOTIN | |||
|
PC-TMEM16 | |||
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