General Information |
|
Product |
PTBP1 Antibody FITC |
Description |
FITC-Conjugated Polypyrimidine tract-binding protein 1 Antibody |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to amino acids within region 150-200 on human Polypyrimidine tract-binding protein 1. |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20?C for long term storage |
|
|
ELISA |
1:50,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500-1:5,000 |
|
|
Uniprot # |
|
Overview |
Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10 (PubMed:15009664). In case of infection by picornaviruses, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:21518806). |
Molecular Function |
mRNA binding poly-pyrimidine tract binding pre-mRNA binding RNA binding |
Subcellular Location |
Nucleus |
Structure |
Monomer. Part of a ternary complex containing KHSRP, PTBP1, PTBP2 and HNRPH1. Interacts with RAVER1 and SFPQ. |
Alternative Nomenclature |
57 kDa RNA-binding protein PPTB-1 antibody Heterogeneous nuclear ribonucleoprotein I antibody Heterogeneous Nuclear Ribonucleoprotein Polypeptide I antibody HNRPI antibody MGC10830 antibody MGC8461 antibody Polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I) antibody Polypyrimidine Tract Binding Protein 1 antibody pPTB antibody PTB 1 antibody PTB 2 antibody PTB 3 antibody PTB 4 antibody PTB antibody PTB T antibody PTBP 1 antibody PTBP1 antibody PTBP1_HUMAN antibody PTBT antibody RNA Binding Protein antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
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PTBP1-101AP | |||
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PTBP1-BIOTIN | |||
|
PC-PTBP1 | |||
|
P-PTBP1 | |||
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