General Information

Product

Synaptophysin Antibody

Description

Affinity Purified Synaptophysin Antibody N-epitope

Verified Applications

CM, ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on human Synaptophysin protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60-0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:100

DOT Blot

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:125

Western Blot

1:1,000

Protein

Uniprot #

P08247

Overview

Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity.

Molecular Function

Cholesterol binding, protein self-association, transporter  activity

Subcellular Location

Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane; Multi-pass membrane protein. Cell junction ›synapse › synaptosome

Expression

Characteristic of a type of small (30-80 nm) neurosecretory vesicles, including presynaptic vesicles, but also vesicles of various neuroendocrine cells of both neuronal and epithelial phenotype.

Structure

Homohexamer or homotetramer. Interacts with SRCIN1.

Alternative Nomenclature

Major synaptic vesicle protein P38 antibody

MRXSYP antibody

Syn p38 antibody

Synaptophysin antibody

SYP antibody

SYPH antibody

SypI antibody

General Information

Product

Syndecan-1 Antibody Affinity Purified

Description

Affinity Purified Syndecan 1 Antibody C-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

C-epitope synthetic peptide taken within amino acid region 250-350 on human Syndecan-1 protein.

Accession #

GenBank: AAH08765.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P18827

Overview

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Molecular Function

Protein C-terminus binding

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain).

Alternative Nomenclature

CD 138 antibody

Heparan sulfate proteoglycan fibroblast growth factor receptor antibody

SDC 1 antibody

SDC antibody

syndecan proteoglycan 1 antibody

General Information

Product

Syndecan-1 Antibody Affinity Purified

Description

Affinity Purified Syndecan 1 Antibody N-epitope

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

N-epitope synthetic peptide taken within amino acid region 1-100 on human Syndecan-1 protein.

Accession #

GenBank: AAH08765.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P18827

Overview

Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

Molecular Function

Protein C-terminus binding

Subcellular Location

Membrane; Single-pass type I membrane protein

Structure

Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain).

Alternative Nomenclature

CD 138 antibody

Heparan sulfate proteoglycan fibroblast growth factor receptor antibody

SDC 1 antibody

SDC antibody

syndecan proteoglycan 1 antibody

General Information

Product

CD56 / NCAM Antibody

Description

Affinity Purified Neural Cell Adhesion Molecule 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 800-847 on human neural cell adhesion molecule 1.

Accession #

GenBank: EAW67208.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

UPI0000EE39A0

Overview

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane.

Molecular Function

Developmental protein; Cell adhesion; Differentiation; Neurogenesis

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Expressed in the fetal and adult brain as well as in Schwann cell culture. Also detected in adult peripheral tissues.

Alternative Nomenclature

antigen MSK39 identified by monoclonal antibody 5.1H11 antibody

antigen recognized by monoclonal antibody 5.1H11 antibody

CD 56 antibody

CD56 antigen antibody

Cell Adhesion Molecule Neural 1 antibody

MSK39 antibody

N CAM 180 antibody

N-CAM-1 antibody

NCAM 120 antibody

NCAM 140 antibody

NCAM antibody

NCAMC antibody

NCAM1 antibody

Neural cell adhesion molecule 1 antibody

Neural cell adhesion molecule NCAM antibody

General Information

Product

Ephrin Receptor A1 Antibody

Description

Affinity Purified Ephrin type-A receptor 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 55-605 on human Ephrin type-A receptor 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21709

Overview

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.

Molecular Function

ATP binding; protein kinase activity; protein kinase binding; transmembrane-ephrin receptor activity

Subcellular Location

Cell membrane; Single-pass type I membrane protein

Expression

Overexpressed in several carcinomas.

Structure

Homodimer. Forms a signaling complex with LCK; PTK2B/PYK2 and PI3-kinase upon activation by EFNA1; regulates T-lymphocytes migration. Interacts (via SAM domain) with ILK (via ANK repeats); stimulated by EFNA1 but independent of the kinase activity of EPHA

Alternative Nomenclature

EPH antibody

EPH receptor A1 antibody

Eph tyrosine kinase 1 antibody

EphA1 antibody

Ephrin receptor Eph A1 antibody

Ephrin type-A receptor 1 antibody

EPHT 1 antibody

Erythropoietin producing hepatoma amplified sequence antibody

Esk antibody

Esk antibody

hEpha1 antibody

MGC163163 antibody

Oncogene EPH antibody

Soluble EPHA1 variant 1 antibody

Soluble EPHA1 variant 2 antibody

Tyrosine protein kinase receptor EPH antibody

General Information

Product

ALDH1A1 Antibody

Description

Affinity Purified Aldehyde Dehydrogenase family 1 member A1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 441-491 on rat retinal dehydrogenase 1 protein.

Accession #

NCBI:  NP_071852

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P51647

Overview

Is capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal.

Molecular Function

Oxidoreductase

Subcellular Location

Cytoplasm

Expression

Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.

Structure

Belongs to the aldehyde dehydrogenase family.

Alternative Nomenclature

Acetaldehyde dehydrogenase 1 antibody

AHD2 antibody

ALDC antibody

Aldehyde dehydrogenase 1 family member A1 antibody

Aldehyde dehydrogenase 1 soluble antibody

Aldehyde dehydrogenase 1A1 antibody

Aldehyde dehydrogenase antibody

Aldehyde dehydrogenase cytosolic antibody

Aldehyde dehydrogenase liver cytosolic antibody

ALDH 1 antibody

ALDH 1A1 antibody

ALDH class 1 antibody

ALDH, liver cytosolic antibody

ALDH-E1 antibody

ALDH1 antibody

ALDH11 antibody

ALDH1A1 antibody

ALHDII antibody

epididymis luminal protein 12 antibody

epididymis luminal protein 9 antibody

epididymis secretory sperm binding protein Li 53e antibody

HEL-S-53e antibody

MGC2318 antibody

PUMB1 antibody

RALDH 1 antibody

Retinal dehydrogenase 1 antibody

General Information

Product

Pax2 Antibody

Description

Affinity Purified Pan Paired box protein Pax-2 Antibody Mid-region

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 255-305 on human PAX2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mid-region

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q02962

Overview

Probable transcription factor that may have a role in kidney cell differentiation. Has a critical role in the development of the urogenital tract, the eyes, and the CNS.

Molecular Function

Developmental protein, core promoter proximal region sequence-specific DNA binding, DNA binding

Subcellular Location

Nucleus

Expression

Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.

Structure

Mainly in fetal kidney and juvenile nephrogenic rests.

Alternative Nomenclature

Paired box 2 antibody

Paired box gene 2 antibody

paired box protein 2 antibody

Paired box protein Pax 2 antibody

Pax 2 antibody

General Information

Product

SHANK3 Antibody

Description

Affinity Purified SH3 and multiple ankyrin repeat domains protein 3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q4ACU6

Overview

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

Molecular Function

GFAP/Homer scaffold activity, identical protein binding, ionotropic glutamate receptor binding, protein C-terminus binding, scaffold protein binding, SH3 domain binding, zinc ion binding

Subcellular Location

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Postsynaptic cell membrane, Synapse

Expression

In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.

Structure

Belongs to the SHANK family.

Contains 6 ANK repeats.

Contains 1 PDZ (DHR) domain.

Contains 1 SAM (sterile alpha motif) domain.

Contains 1 SH3 domain.

Alternative Nomenclature

AI841104 antibody

DEL22q13.3 antibody

KIAA1650 antibody

Proline-rich synapse-associated protein 2 antibody

PSAP2 antibody

SH3 and multiple ankyrin repeat domains 3 antibody

SH3/ankyrin domain gene 3 antibody

SHAN3_HUMAN antibody

Shank postsynaptic density protein antibody

Shank3 antibody

Shank3b antibody

SPANK 2 antibody

General Information

Product

Myeloid Marker Antibody

Description

Affinity Purified Myeloid-associated differentiation marker Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat

Predicted: Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 250-300 on rat Myeloid-associated differentiation marker.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q6VBQ5

Molecular Function

establishment of endothelial barrier

membrane raft organization

negative regulation of actin filament polymerization

negative regulation of gene expression

negative regulation of heterotypic cell-cell adhesion

negative regulation of protein kinase C

Subcellular Location

Membrane Curated; Multi-pass membrane protein

Expression

Widely expressed. Not detected in thymus.

Structure

Belongs to the MAL family.

Contains 2 MARVEL domains.

Alternative Nomenclature

myadm
MYADM_HUMAN
myeloid associated differentiation marker
Myeloid upregulated protein
Protein SB135
SB135

General Information

Product

Phospho-Doublecortin Antibody

Description

Affinity Purified Phosphorylated Neuronal migration protein doublecortin Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Mesencephalic astrocyte-derived neurotrophic factor.

Accession #

NCBI:  NP_835365

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Modification

Phosphorylated

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

O43602

Overview

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.

Molecular Function

Developmental protein

Subcellular Location

Cytoplasm, Cell projection

Expression

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Structure

Contains 2 doublecortin domains.

Alternative Nomenclature

DBCN antibody
Dbct antibody
DC antibody
DCX antibody
Doublecortex antibody
Doublin antibody
Lis X antibody
Lissencephalin X antibody
Lissencephaly X linked doublecortin antibody
LISX antibody
Neuronal migration protein doublecortin antibody
SCLH antibody
XLIS antibody