General Information
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Product
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WWOX2 Peptide
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Description
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Antigenic Blocking Peptide Abberant WW domain-containing Oxidoreductase
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Verified Applications
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Immunocompetition, Immunodepletion
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Peptide Description
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Synthetic Peptide
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Accession #
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GenBank: AAL05451.1
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q9NZC7
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Overview
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Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
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Molecular Function
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Coenzyme binding; protein dimerization activity; cofactor binding;
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Subcellular Location
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Cytoplasm. Nucleus. Mitochondrion. Golgi apparatus
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Expression
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Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
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Structure
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Interacts with TP53, p73/TP73 and MAPK8. Interacts with MAPT/TAU, RUNX2 and HYAL2 (By similarity). Forms a ternary complex with TP53 and MDM2. Interacts with ERBB4, LITAF and WBP1. Interacts with DVL1, DVL2 and DVL3. May interact with FAM189B and SCOTIN.
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Alternative Nomenclature
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FOR antibody
FOR II protein antibody
FOR1 antibody
FRA16D antibody
Fragile 16D oxido reductase antibody
Fragile site FRA16D oxidoreductase antibody
Putative oxidoreductase antibody
WOX1 antibody
WW domain containing oxidoreductase antibody
WW domain containing protein WWOX antibody
WW domain oxidoreductase antibody
WWOX antibody
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