General Information |
|
Product |
Insulin degrading enzyme Antibody FITC-Conjugated |
Verified Applications |
ELISA, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human |
Immunogen |
Synthetic peptide taken within amino acid region 100-150 on human Insulin-degrading enzyme protein. |
Accession # |
GenBank: EAW50092.1 |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.55-0.75 µg/µl in antibody stabilization buffer |
Form |
FITC-Conjugated |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunoprecipitation |
1:150 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia. |
Molecular Function |
ATPase activity; Ubiquitin Binding; Zinc ion binding; Insulin binding; Hydrolase; Metalloprotease; Protease |
Subcellular Location |
Cytoplasm; Cell membrane; Secreted |
Structure |
Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus. |
Alternative Nomenclature |
Abeta-degrading protease antibody FLJ35968 antibody Ide antibody insulin protease antibody Insulin-degrading enzyme antibody insulinase antibody insulysin antibody |
Protein information supplied by UniProt
Product | Note | Status | Price | |
---|---|---|---|---|
|
IDE-101AP | |||
|
P-IDE | |||
|
IDE-BIOTIN | |||
|
PC-IDE | |||
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