General Information |
|
Product |
Von Hippel Lindau Antibody FITC |
Description |
FITC-Conjugated Von Hippel-Lindau disease tumor suppressor Antibody |
Verified Applications |
ELISA, IHC, IP, WB |
Immunogen |
Synthetic peptide taken within amino acid region 130-200 on human Von Hippel-Lindau disease tumor suppressor protein. |
Host |
Rabbit |
Species Cross Reactivity |
Human, Monkey, Mouse, Rat |
|
|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.5-1.5 µg/µl in antibody stabilization buffer |
Immunoglobulin |
IgG |
Form |
FITC-Conjugated |
Purification Method |
Immobilized antigen affinity chromatography |
Clonality |
Polyclonal |
Storage |
-20⁰C for long term storage |
|
|
ELISA |
1:10,000 |
Immunocytochemistry |
1:50-1:150 |
Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation |
1:200 |
Western Blot |
1:500 |
|
|
Uniprot # |
|
Overview |
Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. |
Molecular Function |
Enzyme binding, Transcription factor binding, Ubiquitin protein ligase activity, |
Subcellular Location |
Cytoplasm, Peripheral membrane protein, nucleus |
Expression |
Expressed in the adult and fetal brain and kidney. |
Structure |
Belongs to the VHL family. |
Alternative Nomenclature |
Elongin binding protein antibody G7 protein antibody HRCA 1 antibody Protein G7 antibody pVHL antibody RCA 1 antibody VHL 1 antibody VHLH antibody Von Hippel Lindau disease tumor suppressor antibody von Hippel Lindau syndrome antibody von Hippel Lindau tumor suppressor antibody Von Hippel Lindau tumor suppressor, E3 ubiquitin protein ligase antibody |
Protein information supplied by UniProt.
Product | Note | Status | Price | |
---|---|---|---|---|
|
PVHL-101AP | |||
|
PVHL-BIOTIN | |||
|
P-PVHL | |||
|
PC-PVHL | |||
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