General Information
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Product
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Sialoadhesin Antibody
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Description
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Affinity Purified CD169 Antibody
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Verified Applications
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ELISA, IHC, IP, WB
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Host
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Rabbit
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Species Cross Reactivity
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Human, Monkey
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Immunogen
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Synthetic peptide taken within amino acid region 10-60 on human Sialoadhesin protein.
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Accession #
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NCBI: NP_075556
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Physical Properties
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Quantity
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100 µg
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Volume
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200 µl
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Concentration
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0.5 µg/µl in antibody stabilization buffer
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Immunoglobulin
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IgG
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Form
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Affinity Purified
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Clonality
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Polyclonal
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Storage
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-20⁰C for long term storage
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Application Protocol
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ELISA
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1:10,000
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Immunohistochemistry |
1:50-1:150 |
Immunoprecipitation
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1:200
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Western Blot
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1:500
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Protein
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Uniprot #
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Q9BZZ2
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Overview
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Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells.Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis.
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Molecular Function
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Carbohydrate binding; Cell adhesion; Endocytosis
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Subcellular Location
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Isoform 1: Cell membrane; Isoform 2: Secreted
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Expression
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Expressed by macrophages in various tissues. High levels are found in spleen, lymph node, perivascular macrophages in brain and lower levels in bone marrow, liver Kupffer cells and lamina propria of colon and lung. Also expressed by inflammatory macrophagrophages in rheumatoid arthritis.
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Structure
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Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 16 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
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Alternative Nomenclature
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CD169 antibody
sialic acid binding Ig-like lectin 1, sialoadhesin antibody
Sialic acid-binding Ig-like lectin 1 antibody
Sialoadhesin antibody
Siglec 1 antibody
SN antibody
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