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PDE1B Antibody

Product no.: PD1B-201AP

$320.00

Description
Publications

General Information
Product	PDE1B Antibody
Description	Affinity Purified Pan Phosphodiesterase 1B Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to unique amino acid sequence on PDE1B gene.
Specificity	This antibody does not cross-react with PDE1A or PDE1C or any known PDE family m ember. This antibody will label all PDE1B variants.
Accession #	GenBank: EDL03912.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.58 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:50-1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:50-1:200
Immunofluorescence	1:50-1:200
Immunohistochemistry	1:50-1:200
Immunoprecipitation	1:200
Western Blot	1:500-1:1,000. Predicted molecular weight: 65 kDa. This antibody labels multiple bands in the 65-72 kDa range all believed to be various PDE1B variants.
Protein
Uniprot #	UPI000154A3CC
Overview	Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate.
Molecular Function	Calmodulin-binding, cAMP, cGMP, Metal-binding
Subcellular Location	Cytoplasm
Structure	Homodimer
Alternative Nomenclature	5''-cyclic nucleotide phosphodiesterase 1B antibody 63 kDa Cam PDE antibody Calcium/calmodulin dependent 3' 5' cyclic nucleotide Phosphodiesterase 1B antibody PDE1B1 antibody Cam PDE 1B antibody PDE1B antibody PDE1B1 antibody PDES 1B antibody Phosphodiesterase 1B antibody Phosphodiesterase 1B calmodulin dependent antibody

Protein information supplied by UniProt

Fabgennix PDE1B Antibody has been used in 10 Publications

Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602

Immunohistochemistry; Human

Yougbaré, Issaka, et al. "Cyclic GMP catabolism up-regulation in MRL/lpr lupus-prone mice is associated with organ remodeling." Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842.7 (2014): 916-926. PMID24631654

Immunohistochemistry, Western Blot; Mouse

Genders, Amanda J., et al. "cGMP phosphodiesterase inhibition improves the vascular and metabolic actions of insulin in skeletal muscle." American Journal of Physiology-Endocrinology and Metabolism 301.2 (2011): E342-E350.

PMID21653225

Immunofluorescence, Western Blot; Rat

Abusnina, Abdurazzag, et al. "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." Cellular signalling 23.1 (2011): 152-160. PMID20807569

Western Blot; Human

Abusnina, Abdurazzag, et al. "Anti‐prolifeRative effect of curcumin on melanoma cells is mediated by PDE1A inhibition that regulates the epigenetic integRator UHRF1." Molecular nutrition & food research 55.11 (2011): 1677-1689. PMID22045655

Western Blot; Human

Dong, Hongli, et al. "Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells." Biochemical pharmacology 79.3 (2010): 321-329. PMID19737543

Western Blot; Human

Tahseldar-Roumieh, Rima et al. “PDEs1-5 Activity and Expression in Tissues of Cirrhotic Rats Reveal a Role for Aortic PDE3 in NO Desensitization.” International Journal of Experimental Pathology 90.6 (2009): 605–614. PMC2803251

Western Blot; Rat

Ortiz-Capisano, M. Cecilia et al. “Calcium-Dependent Phosphodiesterase 1C Inhibits Renin Release from Isolated Juxtaglomerular Cells.” American Journal of Physiology - Regulatory, Integrative and Comparative Physiology297.5 (2009): R1469–R1476. PMC2853420

Western Blot; Mouse

Dlaboga, Daniel, Hassan Hajjhussein, and James M. O'Donnell. "Chronic haloperidol and clozapine produce different patterns of effects on phosphodiesterase-1B,-4B, and-10A expression in Rat striatum." Neuropharmacology 54.4 (2008): 745-754. PMID18222493

Western Blot; Rat

Baxendale, Rhona W., and Lynn R. Fraser. "Mammalian sperm phosphodiesterases and their involvement in receptor‐mediated cell signaling important for capacitation." Molecular reproduction and development 71.4 (2005): 495-508. PMID15856425

Immunofluorescence, Western Blot; Mouse

Publishing research using PD1B-201AP? Please let us know, we can cite the reference in this datasheet.

Accessories

Product

Note

Status

Price

PDE1B Antibody FITC

PD1B-FITC

$375.00 *

PDE1B Antibody BIOTIN

PD1B-BIOTIN

$375.00 *

PDE1B Blocking Peptide

P-PD1B

$155.00 *

PDE1B Positive Control

PC-PD1B

$220.00 *

General Information
Product	PGCA Antibody
Description	Affinity Purified Atrial natriuretic peptide receptor 1 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide corresponding to C terminal amino acids 1042-1057 of Human PGCA. Seqence: VRTYWLLGERGCSTRG
Specificity	Will label a 127 to 130 kDa protein in various tissues. Will label only PGCA, but not other Particulate Guanylate Cyclases.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.85 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:25-1:250
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:25-1:250
Immunofluorescence	1:25-1:250
Immunohistochemistry	1:25-1:250
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P16066
Overview	Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Molecular Function	ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity
Subcellular Location	Membrane; Single-pass type I membrane protein
Structure	Homodimer
Alternative Nomenclature	ANP A antibody Atrial natriuretic peptide A type receptor antibody Atrial natriuretic peptide receptor 1 antibody GC A antibody GC-A antibody Guanylate cyclase A antibody NPR 1 antibody NPR A antibody

PGCB-201AP PGCB Antibody $320.00 *	PGCC-301AP Particulate Guanylate Cyclase C Antibody $320.00 *	PGCD-401AP PGCD Antibody $285.00 *
PGCE-501AP PGCE Antibody $320.00 *	PGCF-601AP PGCF Antibody $320.00 *	PGCG-701AP PGCG Antibody $320.00 *
PPGCA-140AP Phospho-PGCA Antibody $375.00 *	PANPRA-140AP Phospho-proANP Antibody $375.00 *

General Information
Product	PGCB Antibody
Description	Affinity Purified Atrial natriuretic peptide receptor 2 Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:50-1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P20594
Overview	Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
Molecular Function	ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity
Subcellular Location	Membrane; Single-pass type I membrane protein
Structure	Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.
Alternative Nomenclature	AMDM antibody ANPB antibody ANPRB antibody peptide receptor type B antibody Atrionatriuretic peptide receptor B antibody GC-B antibody GUCY2B antibody Natriuretic peptide receptor B/guanylate cyclase B antibody NPR-B antibody NPR2 antibody NPRBi antibody

PGCA-101AP PGCA Antibody $320.00 *	PGCC-301AP Particulate Guanylate Cyclase C Antibody $320.00 *	PGCD-401AP PGCD Antibody $285.00 *
PGCE-501AP PGCE Antibody $320.00 *	PGCF-601AP PGCF Antibody $320.00 *	PGCG-701AP PGCG Antibody $320.00 *
NPRC-301AP Natriuretic Peptide Receptor C Antibody $285.00 *	PBNP-101AP proBNP Antibody $285.00 *	PANPRA-140AP Phospho-proANP Antibody $375.00 *
PPGCA-140AP Phospho-PGCA Antibody $375.00 *

General Information
Product	Particulate Guanylate Cyclase C Antibody
Description	Affinity Purified Guanlylyl Cyclase C Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase C protein.
Accession #	GenBank: AAA41201.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Western Blot	1:500
Protein
Uniprot #	P23897
Overview	Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.
Molecular Function	Lyase, Receptor
Subcellular Location	Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane
Structure	Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36
Alternative Nomenclature	ANP C antibody ANPRC antibody Atrial natriuretic peptide C type receptor antibody Atrionatriuretic peptide receptor C antibody C5orf23 antibody FLJ14054 antibody GUCY2B antibody MGC22189 antibody Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) antibody NPR 3 antibody NPR C antibody Guanylyl Cyclase C antibody NPR-C antibody

General Information
Product	PGCD Antibody
Description	Affinity Purified Guanlylyl Cyclase D Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase D protein.
Accession #	GenBank: AAC42057.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Immunoprecipitation	1:200
Western Blot	1:500
Protein
Uniprot #	P51839
Overview	May function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.
Molecular Function	Lyase
Subcellular Location	Membrane; Single-pass type I membrane protein
Expression	Specifically expressed in a subpopulation of olfactory sensory neurons.
Structure	Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.
Alternative Nomenclature	CORD6 antibody guanylate cyclase 2D membrane (retina-specific) antibody GUC1A4 antibody GUC2D antibody LCA1 antibody retGC antibody RETGC-1 antibody ROS-GC1 antibody

General Information
Product	PGCE Antibody
Description	Affinity Purified Guanylyl cyclase E Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase E protein.
Accession #	GenBank: L36029.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Western Blot	1:500
Protein
Uniprot #	P51840
Overview	GTP = 3',5'-cyclic GMP + diphosphate.
Molecular Function	Lyase
Subcellular Location	Membrane; Single-pass type I membrane protein
Expression	Expressed in the eye and the pineal gland.
Structure	Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.
Alternative Nomenclature	Particulate Guanylate Cyclase E antibody

General Information
Product	PGCF Antibody Affinity Purified
Description	Affinity Purified Guanylyl Cyclase F Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase F protein.
Accession #	GenBank: L36029.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Western Blot	1:500
Protein
Uniprot #	P51842
Overview	Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.
Molecular Function	Lyase
Subcellular Location	Membrane; Single-pass type I membrane protein
Expression	Expressed only in the eye.
Structure	Belongs to the adenylyl cyclase-class-4/guanylyl cyclase family. Contains 1 guanylate cyclase domain. Contains 1 protein kinase domain.
Alternative Nomenclature	Particulate Guanylate Cyclase F antibody

General Information
Product	PGCG Antibody
Description	Affinity Purified Guanylyl Cyclase G Antibody
Verified Applications	CM, ELISA, ICC, IF, IHC, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase G protein.
Accession #	GenBank: AF024622.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.75-1.20 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
Confocal Microscopy	1:200
DB	1:10,000
ELISA	1:10,000
Immunocytochemistry	1:200
Immunofluorescence	1:200
Immunohistochemistry	1:200
Western Blot	1:500
Protein
Uniprot #	P55205
Overview	Binds to a yet not identified ligand. Possible role in processes such as water and electrolyte balance, and muscle contraction.
Molecular Function	Lyase, Receptor
Subcellular Location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm
Expression	Expressed in lung, kidney and skeletal muscle. Low levels in intestine.
Structure	Homodimer or heterodimer with NPR1.
Alternative Nomenclature	CYGF antibody GC F antibody guanylate cyclase 2D-like, membrane (retina-specific) antibody Guanylate cyclase 2F antibody GUC2DL antibody GUC2F antibody Gucy2f antibody RETGC-2 antibody retinal antibody Rod outer segment membrane guanylate cyclase 2 antibody ROS-GC2 antibody

General Information
Product	Phospho PGCA Antibody
Description	Affinity Purified Atrial Natriuretic peptide receptor 1 Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rat
Immunogen	Synthetic peptide taken within amino acid region 500-550 on human Atrial natriuretic peptide receptor 1 protein.
Accession #	NCBI: XP_011507887.1
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.55-0.75 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Uniprot #	P16066
Overview	Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
Molecular Function	ATP binding, GTP binding, hormone binding, Protein kinase activity, G-protein coupled peptide receptor activity
Subcellular Location	Membrane; Single-pass type I membrane protein
Structure	Homodimer
Alternative Nomenclature	ANP A antibody ANPR-A antibody Atrial natriuretic peptide A type receptor antibody Atrial natriuretic peptide receptor 1 antibody Atrionatriuretic peptide receptor A antibody GC A antibody Guanylate cyclase A antibody Guanylate cyclase antibody GUC2A antibody Natriuretic peptide A type receptor antibody Natriuretic peptide receptor A/guanylate cyclase A antibody NPR 1 antibody NPR A antibody

General Information
Product	PREX1 Antibody
Description	Affinity Purified Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein Antibody
Verified Applications	ELISA, IHC, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Monkey, Mouse, Rat
Immunogen	Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified. Sequence: QEEDQADSAFPLLSLGPRLSLC
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.6 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:20,000-1:50,000
ELISA	1:20,000-1:50,000
Immunohistochemistry	1:50-1:150
Immunoprecipitation	1:500
Western Blot	1:500-1:750
Protein
Uniprot #	Q8TCU6
Overview	Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Molecular Function	enzyme binding, Rho GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, phospholipid binding
Subcellular Location	Cytoplasm, cell membrane
Expression	Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Alternative Nomenclature	4 antibody 5)-dependent Rac exchanger 1 antibody P REX1 antibody PtdIns(3,4,5) dependent Rac exchanger 1 antibody SET domain containing 6 antibody Setd6 antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP PDE1B Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP PGCA Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP PGCB Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP Particulate Guanylate Cyclase C Antibody

Home page Primary Antibodies Signal Transduction Guanylate Cyclases & GTPases PGCD Antibody

Home page Primary Antibodies Signal Transduction Guanylate Cyclases & GTPases PGCE Antibody

Home page Primary Antibodies Signal Transduction Guanylate Cyclases & GTPases PGCF Antibody

Home page Primary Antibodies Metabolism & Homeostasis PGCG Antibody

Home page Primary Antibodies Signal Transduction Second Messengers cGMP Phospho-PGCA Antibody

Home page Primary Antibodies Signal Transduction Guanylate Cyclases & GTPases PREX1 Antibody

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