General Information |
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Product |
PDE4D Peptide |
Description |
Antigenic Blocking Peptide Phosphodiesterase 4D |
Verified Applications |
Immunodepletion, Immunocompetition |
Peptide Description |
C-terminal cyclic peptide unique to all PDED subtypes variants. |
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|
Quantity |
250 µg |
Volume |
100 µl |
Form |
Antigenic Blocking Peptide |
Storage |
-20⁰C for long term storage |
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Competition/Depletion assay |
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Overview |
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. |
Molecular Function |
Hydrolase, 3',5'-cyclic-AMP phosphodiesterase activity, cAMP binding |
Subcellular Location |
Apical cell membrane, Cytoplasm, Membrane |
Expression |
Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. |
Structure |
Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). |
Alternative Nomenclature |
cAMP specific 3',5' cyclic phosphodiesterase 4D antibody DKFZp686M11213 antibody 5''-cyclic phosphodiesterase 4D antibody cAMP specific phosphodiesterase PDE4D antibody cAMP specific phosphodiesterase PDE4D6 antibody DPDE 3 antibody Dunce like phosphodiesterase E3 antibody FLJ97311 antibody HSPDE4D antibody PDE 43 antibody PDE4DN2 antibody Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody Drosophila antibody STRK1 antibody |
Protein information supplied by UniProt
Fabgennix PDE4D Antibody has been used in 37 Publications |
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Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602 |
Immunohistochemistry; Human |
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Guo, Jiejie, et al. "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." Neuroscience 263 (2014): 1-14. PMID24434771 |
Western Blot; Mouse |
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Dong, Cun-Jian, et al. "Presynaptic Inhibition by α2 Receptor/Adenylate Cyclase/PDE4 Complex at Retinal Rod Bipolar Synapse." The Journal of Neuroscience 34.28 (2014): 9432-9440. PMID25009274 |
Immunohistochemistry; Rat |
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Zhai, Kui, et al. "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." Cellular signalling 26.5 (2014): 1001-1010. PMID24463006 |
Western Blot; Rat |
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Salazar, Norma C et al. “GRK2 Blockade with βARKct Is Essential for Cardiac Β2-Adrenergic Receptor Signaling Towards Increased Contractility.” Cell Communication and Signaling : CCS 11 (2013): 64. PMC3846709 |
Immunoprecipitation, Western Blot; Mouse |
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Al-Tawashi, Azza, and Chris Gehring. “Phosphodiesterase Activity Is Regulated by CC2D1A That Is Implicated in Non-Syndromic Intellectual Disability.” Cell Communication and Signaling?: CCS 11 (2013): 47. PMC3704924 |
Immunocytochemistry, Western Blot; Mouse |
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Wang, Zhen-Zhen et al. “RNA Interference-Mediated Phosphodiesterase 4D Splice Variants Knock-down in the Prefrontal Cortex Produces Antidepressant-Like and Cognition-Enhancing Effects.” British Journal of Pharmacology 168.4 (2013): 1001–1014. PMC3631387 |
Western Blot; Mouse |
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Michalski, Joel, et al. "Attenuation of inhibitory prostaglandin E2 signaling in Human lung fibroblasts is mediated by phosphodiesterase 4." American journal of respiratory cell and molecular biology 47.6 (2012): 729-737. PMID23043089 |
Western Blot; Human |
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Al-Tawashi, Azza et al. “Protein Implicated in Nonsyndromic Mental Retardation Regulates Protein Kinase A (PKA) Activity.” The Journal of Biological Chemistry 287.18 (2012): 14644–14658. PMC3340277 |
Immunohistochemistry, Western Blot; Mouse |
Click Here for the complete list of all FabGennix PDE4D publications
Publishing research using PD4-401AP? Please let us know, we can cite the reference in this datasheet.
Product | Note | Status | Price | |
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PD4-401AP | |||
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PD4D-FITC | |||
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PD4D-BIOTIN | |||
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PC-PD4D | |||
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