General Information |
|
Product |
Pan PDE2A Antibody BIOTIN-Conjugated |
Description |
BIOTIN-Conjugated Phosphodiesterase 2A, cGMP-stimulated Antibody C-epitope |
Verified Applications |
CM, ELISA, FRET, ICC/IF, IHC, IP, WB |
Host |
Rabbit |
Species Cross Reactivity |
Human, Mouse, Rat |
Immunogen |
Synthetic peptide corresponding to unique C-terminal amino acid sequence on PDE2A gene. |
Specificity | This antibody will label PDE2A1, PDE2A2, PDE2A3 and PDE2A4 variants. |
Accession # |
GenBank: EAW74861.1 |
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|
Quantity |
100 µg |
Volume |
200 µl |
Concentration |
0.7 µg/µl in antibody stabilization buffer |
Form |
BIOTIN-Conjugated |
Clonality |
Polyclonal |
Determinant |
C-epitope |
Storage |
-20⁰C for long term storage |
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|
Confocal Microscopy |
1:250-1:1,000 |
DB |
1:10,000 |
ELISA |
1:10,000 |
Immunocytochemistry |
1:250-1:1,000 |
Immunofluorescence |
1:150-1:1,000 |
Immunohistochemistry |
1:250-1:1,000 |
Immunoprecipitation |
1:200 |
Western Blot |
1:250-1:1,000 |
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|
Uniprot # |
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Overview |
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis. |
Molecular Function |
Hydrolase, cAMP, cGMP, Metal-binding, Angiogenesis |
Subcellular Location |
Multi-pass membrane protein |
Expression |
bundant in adipose tissues. |
Structure |
Interacts with PIK3CG (By similarity). Interacts with RAPGEF3 and PIK3R6. |
Alternative Nomenclature |
5''-cyclic phosphodiesterase antibody cGMP dependent 3'5' cyclic phosphodiesterase antibody cGMP stimulated phosphodiesterase 1 antibody cGMP stimulated phosphodiesterase 4 antibody cGMP-dependent 3'' antibody CGS PDE antibody Cyclic GMP stimulated phosphodiesterase antibody PDE 2A antibody PDE 2A1 antibody PDE 2A4 antibody PDE2A antibody Phosphodiesterase 2A cGMP stimulated antibody |
Protein information supplied by UniProt
Fabgennix PDE2A Antibody has been used in 35 Publications |
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Fields, Laura A., Andreas Koschinski, and Manuela Zaccolo. "Sustained exposure to catecholamines affects cAMP/PKA compartmentalised signalling in adult rat ventricular myocytes." Cellular signalling (2015). PMID26475678
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Confocal imaging, FRET, Western Blot; Rat |
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602
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Immunohistochemistry; Human |
Petersen, T. S., et al. "Distribution and function of 3', 5'-Cyclic-AMP phosphodiesterases in the human ovary." Molecular and cellular endocrinology (2015). PMID25578602
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Immunohistochemistry; Human |
Kedia, George T., et al. "Expression and Distribution of Phosphodiesterase Isoenzymes in the Human Male Urethra." Urology (2015). PMID25704994
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Immunohistochemistry, Western Blot; Human |
Rajagopal, Senthilkumar, et al. "Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation." Journal of Pharmacology and Experimental Therapeutics 352.3 (2015): 509-518. PMID25550199
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Western Blot; Mouse |
For a complete listing of FabGennix PDE2A publications, please click here.
Publishing research using PD2A-101AP? Please let us know, we can cite the reference in this datasheet.
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