General Information
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Product
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DNA polymerase eta Peptide
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Description
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Antigenic Blocking Peptide Chain B, Yeast DNA polymerase Eta Antibody
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Verified Applications
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Immunodepletion, Immunocompetition
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Peptide Description
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Synthetic Peptide
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Accession #
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NCBI: 1JIH_A
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Physical Properties
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Quantity
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250 µg
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Volume
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100 µl
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Form
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Antigenic Blocking Peptide
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Storage
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-20⁰C for long term storage
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Application Protocol
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Competition/Depletion assay
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Refer to competition assay protocol
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Protein
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Uniprot #
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Q04049
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Overview
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DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Plays an important role in the repair of UV-induced pyrimidine dimers. Depending on the context, it inserts the correct base, but causes frequent base transitions and transversions. Efficiently incorporates nucleotides opposite to other UV or oxidative DNA damages like O(6)-methylguanine, 7,8-dihydro-8-oxoguanine, 2,6-diamino-4-hydroxy-5-formamidopyrimidine of 2'-deoxyguanosine (FaPydG), or p-benzoquinone DNA adducts.
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Molecular Function
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Damaged DNA binding, Metal ion binding, DNA-directed DNA polymerase activity
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Subcellular Location
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Nucleus
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Expression
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Induced by UV radiation and heat shock. The mRNA is stabilized during stationary phase.
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Structure
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Interacts with POL30. This interaction is essential for the polymerase eta function.
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Alternative Nomenclature
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DNA polymerase eta antibody
FLJ16395 antibody
FLJ21978 antibody
POLH antibody
polymerase DNA directed eta antibody
RAD30 antibody
RAD30 homolog A antibody
Xeroderma pigmentosum variant type protein antibody
XPV antibody
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