Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape.
Molecular Function
guanyl-nucleotide exchange factor activity
metal ion binding
Rho guanyl-nucleotide exchange factor activity
small GTPase binding
Subcellular Location
Cytoplasm
Structure
Repeat, Zinc-finger
Alternative Nomenclature
Faciogenital dysplasia 3 antibody
FGD1 family, member 3 antibody
FGD3 antibody
FYVE antibody
FYVE, RhoGEF and PH domain containing 3 antibody
ZFYVE5 antibody
Zinc finger FYVE domain containing protein 5 antibody